Digestive Diseases and Sciences

, Volume 46, Issue 8, pp 1779–1783 | Cite as

Bile Acid Reflux and Possible Inhibition of Helicobacter pylori Infection in Subjects Without Gastric Surgery

  • Yukinobu Kawai
  • Susumu Tazuma
  • Masaki Inoue


Bile acids are generally known to inhibit growth of Helicobacter pylori in vitro, but whether they do so in humans with no gastric surgery has been uncertain. The present study addresses this issue. Among healthy control subjects with preserved acid secretion, H. pylori-positive subjects were older and had lower gastric bile acid concentrations than H. pylori-negative subjects (P < 0.05). Among gastric ulcer patients with preserved acid secretion, H. pylori-positive patients had a higher basal acid output than H. pylori-negative patients (P < 0.05). Among H. pylori-positive subjects with preserved acid secretion, duodenal ulcer patients had a higher basal and maximum acid output than healthy control subjects (P < 0.01). In conclusion, gastric bile acids may suppress initial stages of H. pylori infection in subjects without gastric surgery. However gastric bile acids may have little effect on peptic ulcer disease, once H. pylori infection is established.

acid output ammonia bile acids gastric juice Helicobacter pylori 


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Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • Yukinobu Kawai
    • 1
  • Susumu Tazuma
    • 1
  • Masaki Inoue
    • 2
  1. 1.First Department of Internal MedicineHiroshima University School of MedicineHiroshimaJapan
  2. 2.Department of Geriatric Medicine, Institute of Health SciencesHiroshima University School of MedicineHiroshimaJapan

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