Abstract
Background: Previous approaches to ventricular volume calculations by 3-dimensional echocardiography (3-DE) required multiple transverse tomographic sectioning and summation of the volumes of parallel disks. These methods were time consuming and beared the risk of missing the apical volume. Methods: We investigated the accuracy of a new, rapid method of 3-DE volume measurements in normal (LV) and aneurysmal (aneurLV) left ventricles in fixed pig hearts. 3-D data sets of 12 LV and 8 experimentally created aneurLV were obtained using a TomTec 3-DE system. For 3-DE volume calculations, a rotational axis in the center of the left ventricle (apical–basal orientation) was defined and 3, 6 and 12 equi-angular rotational planes were created. In each plane the endocardial border was traced and the volume of the corresponding wedge was automatically calculated. The measurements were performed by 2 independent investigators blinded to the anatomic volume and were analyzed for inter- and intraobserver variability. Results: The anatomic volumes ranged from 5 to 150 ml and 9 to 40 ml in LV and aneurLV, respectively. The correlation between 3-DE and anatomic volume was excellent for LV and aneurLV traced in 3, 6 and 12 planes (r = 0.94–0.99). Ventricular volume was well predicted by 3-DE reconstruction: SEE 5.5–7.1 ml (LV), 3.0–3.2 ml (aneurLV). The correlation for interobserver measurements was good in both, LV (r = 0.99) and aneurLV (r = 0.94–0.99) even in 3 planes. The intra- and interobserver variabilities were 1.6–3.0 ml (<7%) and 7.2–7.3 ml (<15%) in LV and 1.1–1.6 (<6%) and 2.1–3.3 ml (<14%) in aneurLV respectively. Conclusion: This new 3-DE method of ventricular volume measurements using a rotational approach provides rapid, accurate and reproducible volume measurements in LV and aneurLV.
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References
Siu SC, Rivera JM, Guerrero JL, et al. Three-dimensional echocardiography. In vivo validation for left ventricular volume and function. Circulation 1993; 88(4 Pt 1): 1715-1723.
Gopal AS, Keller AM, Rigling R, et al. Left ventricular volume and endocardial surface area by three-dimensional echocardiography: comparison with two-dimensional echocardiography and nuclear magnetic resonance imaging in normal subjects. J Am Coll Cardiol 1993; 22(1): 258-270.
Siu SC, Levine RA, Rivera JM, et al. Three-dimensional echocardiography improves noninvasive assessment of left ventricular volume and performance. Am Heart J 1995; 130(4): 812-822.
Sapin PM, Schroder KM, Gopal AS, et al. Comparison of two-and three-dimensional echocardiography with cineventriculography for measurement of left ventricular volume in patients. J Am Coll Cardiol 1994; 24(4): 1054-1063.
Sawada H, Fujii J, Kato K, Onoe M, Kuno Y. Three dimensional reconstruction of the left ventricle from multiple cross sectional echocardiograms. Value for measuring left ventricular volume. Br Heart J 1983; 50(5): 438-442.
Hibberd MG, Siu SC, Handschumacher MD, et al. Three-dimensional echocardiography: increased accuracy for left ventricular volume compared with angiography. Circulation 1992; 86(suppl I): I-270.
Sapin PM, Schroeder KD, Smith MD, Demaria AN, King DL. Three-dimensional echocardiographic measurement of left ventricular volume in vitro: comparison with two-dimensional echocardiography and cineventriculography. J Am Coll Cardiol 1993; 22(5): 1530-1537.
Jiang L, Vazquez de Prada JA, Handschumacher MD, et al. Quantitative three-dimensional reconstruction of aneurysmal left ventricles. In vitro and in vivo validation. Circulation 1995; 91(1): 222-230.
Kupferwasser I, Mohr-Kahaly S, Stahr P, et al. Transthoracic three-dimensional echocardiographic volumetry of distorted left ventricles using rotational scanning. J Am Soc Echocardiogr 1997; 10(8): 840-852.
Buck T, Schon F, Baumgart D, et al. Tomographic left ventricular volume determination in the presence of aneurysm by three-dimensional echocardiographic imaging. I: Asymmetric model hearts. J Am Soc Echocardiogr 1996; 9(4): 488-500.
Krebs W, Klues HG, Steinert S, et al. Left ventricular volume calculations using a multiplanar transoesophageal echoprobe; in vitro validation and comparison with biplane angiography. Eur Heart J 1996; 17(8): 1279-1288.
Yao J, Kasprzak JD, Nosir YF, et al. Appropriate 3-dimensional echocardiography data acquisition interval for left ventricular volume quantification: implications for clinical application. J Am Soc Echocardiogr 1999; 12(12): 1053-1057.
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Teupe, C., Takeuchi, M., Ram, S. et al. Three-dimensional echocardiography: In-vitro validation of a new, voxel-based method for rapid quantification of ventricular volume in normal and aneurysmal left ventricles. Int J Cardiovasc Imaging 17, 99–105 (2001). https://doi.org/10.1023/A:1010671305700
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DOI: https://doi.org/10.1023/A:1010671305700