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Helicobacter pylori Infection and Gastric Function in Patients with Fundic Atrophic Gastritis

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Abstract

In the present study we evaluated the relation among histology, H. pylori, IgG to H. pylori, gastric emptying, and acid secretion in 43 patients with fundic atrophic gastritis. On the basis of gastric acid secretion, patients were divided into three subgroups: patients with preserved acid secretion (Group 1), patients with hypochlorhydria (Group 2), and patients with achlorhydria (Group 3). Fundic glandular atrophy was more severe in hypoachlorhydric patients than in those with preserved acid secretion (P < 0.05 vs Group 2, P < 0.005 vs Group 3). H. pylori colonization was found in 94% of patients in Group 1, in 61% of patients in Group 2, and in only 8% of patients in Group 3 (P < 0.001 vs Group 1, P < 0.05 vs Group 2). Conversely, serological positivity to H. pylori was high in all three subgroups of patients (100% in Group 1, 77% in Group 2, 92% in Group 3). Gastric emptying was delayed in atrophic patients, particularly in those with hypoachlorhydria. Our data suggest that fundic atrophic gastritis represents a possible end stage of H. pylori infection, characterized by a progressive disappearance of the bacterium and a progressive deterioration of gastric functions.

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Authors and Affiliations

  1. Department of Internal Medicine & Gastroenterology, Hospital S. Orsola-Malpighi, University of Bologna, Bologna, Italy

    Antonio Tucci, Loris Poli, Guido Biasco, Gioyanni F. Paparo, Cesare Tosetti, Pietro Fusaroli, Antonio M. Morselli Labate, Vincenzo Stanghellini & Giancarlo Caletti

  2. Institute of Microbiology, Hospital S. Orsola-Malpighi, University of Bologna, Bologna, Italy

    Vittorio Sambri & Manuela Donati

  3. Department of Pathology, Hospital S. Orsola-Malpighi, University of Bologna, Bologna, Italy

    Walter Grigioni

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  1. Antonio Tucci
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  2. Loris Poli
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Tucci, A., Poli, L., Biasco, G. et al. Helicobacter pylori Infection and Gastric Function in Patients with Fundic Atrophic Gastritis. Dig Dis Sci 46, 1573–1583 (2001). https://doi.org/10.1023/A:1010668727340

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