Skip to main content
SpringerLink
Log in

CASE REPORT: Hepatotoxicity in Patients with Cirrhosis, an Often Unrecognized Problem

  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Zimmerman HJ: Hepatotoxicity. The Adverse Effects of Drugs and Other Chemicals on the Liver, 2nd ed. Philadelphia, Lippincott Williams & Wilkins, 1999

    Google Scholar 

  2. Blaise M, Pateron D, Trinchet JC, Levacher S, Beaugrand M, Pourriat JL: Systemic antibiotic therapy prevents bacterial infection in cirrhotic patients with gastrointestinal hemorrhage. Hepatology 20:34–38, 1994

    Google Scholar 

  3. Rimola A, Garcia-Tsao G, Navasa M, Piddock LJV, Planas R, Bernard B, Inadomi JM, International Ascites Club: Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: A consensus document. J Hepatol 32:142–153, 2000

    Google Scholar 

  4. Verhamme M, Ramboer C, Van De Bruaue P, Inderadjaja N: Cholestatic hepatitis due to an amoxycillin/clavulanic acid preparation. J Hepatol 9:260–264, 1989

    Google Scholar 

  5. Nathani MG, Mutchnick MG, Tynes DJ, Ehrinpreis MN: An unusual case of amoxicillin/clavulanic acid-related hepatotoxicity. Am J Gastroenterol 93:1363–1365, 1998

    Google Scholar 

  6. Reddy KR, Brillant P, Schiff ER: Amoxicillin-clavulanate potassium-associated cholestasis. Gastroenterology 96:1135–1141, 1989

    Google Scholar 

  7. Larrey D, Vial T, Micaleff A, Babary G, Moricheau-Brauchnt M, Michel H, Benhamou JP: Hepatitis associated with amoxycillin-clavulanic acid combination. Report of 15 cases. Gut 33:368–371, 1992

    Google Scholar 

  8. Hautekeete ML, Brenard R, Horsmans Y, Henrion J, Verbist L, Derue G, Druez P, Omar M, Kockx M, Hubens H, Haber I, Rahier J, Geubel AP: Liver injury related to amoxycillinclavulanic acid: Interlobular bile-duct lesions and extrahepatic manifestations. J Hepatol 22:71–77, 1995

    Google Scholar 

  9. Hebbard GS, Smith KG, Gibson PR, Bhathal PS: Augmentininduced jaundice with a fatal outcome. Med J Aust 156:285–286, 1992

    Google Scholar 

  10. Danan G, Bénichou C: Causality assessment on adverse reactions to drugs I. A novel method based on the conclusions of international consensus meetings: Application to drug-induced liver injuries. J Clin Epidemiol 46:1323–1330, 1993

    Google Scholar 

  11. Maria VAJ, Victorino RMM: Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis. Hepatology 26:664–669, 1997

    Google Scholar 

  12. Benazzi F: Risperidone-induced hepatotoxicity. Pharmacopsychiatry 31:241, 1998

    Google Scholar 

  13. Medicine Control Agency: Cholestatic jaundice with coamoxiclav. Curr Probl Pharmacov 19:2, 1993

    Google Scholar 

  14. Ragg M: MaLam and augmentin. Lancet 2:487, 1993

    Google Scholar 

  15. Hautekeete ML, Horsmans Y, Van Waeyenberge C, Demanet C, Henrion J, Verbist L, Brenard R, Sempoux C, Michielsen PP, Yap PSH, Rahier J, Geubel AP: HLA association of amoxicillin-clavulanate-induced hepatitis. Gastroenterology 117:1181–1186, 1999

    Google Scholar 

  16. Westphal J-F, Brogard J-M: Drug administration in chronic liver disease. Drug Safety 17:47–73, 1997

    Google Scholar 

  17. Schenker S, Martin RR, Hoyumpa AM: Antecedent liver disease and drug toxicity. J Hepatol 31:1098–1105, 1999

    Google Scholar 

  18. Garcia-Rodriguez LA, Stricker BH, Zimmerman HJ: Risk of acute liver injury associated with the combination of amoxicillin and clavulanic acid. Arch Intern Med 156:1327–1332, 1996

    Google Scholar 

  19. Grange JD, Amiot X, Grange V, Gutmann L, Biour M, Bodin F, Poupon R: Amoxicillin-clavulanic acid therapy of spontaneous bacterial peritonitis: A prospective study of twenty-seven cases in cirrhotic patients. Hepatology 11:360–364, 1990

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Unidad de Hepatología and Servicio de Farmacología Clínica, Hospital Universitario Virgen de la Victoria, Facultad de Medicina, Campus Universitario de Teatinos s/n, Málaga, Spain

    Raúl J. Andrade, Isabel Lucena & Raquel Camargo

  2. Servicios de Farmacologia Clinica and Gastroenterologia, Hospital Torrecárdenas, Almeria, Spain

    Carmen Fernández & Jose L. Vega

Authors
  1. Raúl J. Andrade
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Isabel Lucena
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Carmen Fernández
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jose L. Vega
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Raquel Camargo
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Andrade, R.J., Lucena, I., Fernández, C. et al. CASE REPORT: Hepatotoxicity in Patients with Cirrhosis, an Often Unrecognized Problem. Dig Dis Sci 46, 1416–1419 (2001). https://doi.org/10.1023/A:1010627518254

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1010627518254

Search

Navigation