Abstract
This article reviews our studies of the γ subunit of the sodium pump. γ is a member of the FXYD family of small, single transmembrane proteins and is expressed predominantly in the kidney tubule. There are two major variants of γ which function similarly to bring about two distinct effects, one on K′ATP and the other, on K K, the affinity of the pump for K + acting as a competitor of cytoplasmic Na+. In this way, γ is believed to provide a self-regulatory mechanism for maintaining the steady-state activity of the pump in the kidney. Our studies also suggest that K+ antagonism of cytoplasmic Na+ activation of the pump is relevant not only to the presence of γ in the kidney, but probably some hitherto undefined factor(s) in other tissues, most notably heart. The interesting possibility that not only γ but other members of the FXYD family regulate ion transport in a tissue-specific manner is discussed.
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Therien, A.G., Pu, H.X., Karlish, S.J.D. et al. Molecular and Functional Studies of the Gamma Subunit of the Sodium Pump. J Bioenerg Biomembr 33, 407–414 (2001). https://doi.org/10.1023/A:1010619623841
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DOI: https://doi.org/10.1023/A:1010619623841