Abstract
Two new dimensionless parameters (Φ and Ω) are proposed for calculating the proportional, integral, and derivative constants of a dissolved oxygen proportional integral-derivative (PID) feed-back control algorithm from knowledge of the growth rate, bioreactor design and operation variables. The values of Φ and Ω were determined for a broad range of Reynolds numbers (between 1000 to 40 000) during the exponential growth phase of two highly different processes: fermentations of recombinant Escherichia coli and cultures of human hematopoietic cells. The utility of Φ and Ω for use in dissolved oxygen self-tunning adaptive control algorithms is discussed.
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De León, A., Barba-de la Rosa, A., Mayani, H. et al. Two useful dimensionless parameters that combine physiological, operational and bioreactor design parameters for improved control of dissolved oxygen. Biotechnology Letters 23, 1051–1056 (2001). https://doi.org/10.1023/A:1010598121587
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DOI: https://doi.org/10.1023/A:1010598121587