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Molecular Biology

, Volume 35, Issue 4, pp 584–590 | Cite as

Cotranslational Protein Folding

  • V. A. Kolb
Article

Abstract

The review analyzes the research concerning the folding of proteins in the course of their synthesis on ribosomes. The experimental data obtained for various proteins using various methods give grounds for concluding that a nascent protein largely acquires its spatial structure while still attached to the ribosome, and final folding into the biologically active conformation takes place as soon as the completed protein is released therefrom. Cotranslational folding is characteristic of both bacterial and eukaryotic cells, and appears to be the universal and the most evolutionarily ancient mechanism.

Keywords

Experimental Data Spatial Structure Eukaryotic Cell Active Conformation Ancient Mechanism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MAIK “Nauka/Interperiodica” 2001

Authors and Affiliations

  • V. A. Kolb
    • 1
  1. 1.Institute of Protein Research, Russian Academy of Sciences, PushchinoMoscow RegionRussia

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