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Genes for the SMC Family Proteins in a Common Vole Microtus arvalis

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Abstract

Genes for four subfamilies of SMC (structural maintenance of chromosomes) proteins have been isolated from the genome of a common vole Microtus arvalis. The high degree of homology between representatives of each SMC protein subfamily of different classes of organisms has been demonstrated. The full-sized copy of a mammalian gene encoding SMC4 protein has been isolated and analyzed for the first time. The SMC proteins enter into the composition of complexes responsible for cohesion of sister chromatids, formation of mitotic chromosomes, recombination, DNA repair, and regulation of gene expression. We discuss the possible participation of the SMC proteins in inactivation of the X chromosome in mammalian females. Common voles of genus Microtusgroup “arvalis” serve a unique model for the study of the inactivation process.

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References

  1. Strunnikov, A.V., Larionov, V.L., and Koshland, D., J. Cell Biol., 1993, vol. 123, pp. 1635–1648.

    Google Scholar 

  2. Strunnikov, A.V., Trends Cell. Biol., 1998, vol. 8, pp. 454–459.

    Google Scholar 

  3. Strunnikov, A.V. and Jessberger, R., Eur. J. Biochem., 1999, vol. 263, pp. 6–13.

    Google Scholar 

  4. Koshland, D. and Strunnikov, A., Annu. Rev. Cell Dev. Biol., 1996, vol. 12, pp. 305–333.

    Google Scholar 

  5. Hirano, T., Mitchison, T.J., and Swedlow, J.R., Curr. Opin. Cell Biol., 1995, vol. 7, pp. 329–336.

    Google Scholar 

  6. Hirano, T., Curr. Opin. Cell Biol., 1998, vol. 10, pp. 17-22.

    Google Scholar 

  7. Jessberger, R., Frei, C., and Gasser, S.M., Curr. Opin. Genet. Dev., 1998, vol. 8, pp. 254–259.

    Google Scholar 

  8. Mengiste, T., Revenkova, E., Bechtold, N., and Paszkowski, J., EMBO J., 1999, vol. 18, pp. 4505–4512.

    Google Scholar 

  9. Fousteri, M.I. and Lehmann, A.R., EMBO J., 2000, vol. 19, pp. 1691–1702.

    Google Scholar 

  10. Michaelis, C., Ciosk, R., and Nasmyth, K., Cell, 1997, vol. 91, pp. 35–45.

    Google Scholar 

  11. Guacci, V., Koshland, D., and Strunnikov, A., Cell, 1997, vol. 91, pp. 47–57.

    Google Scholar 

  12. Heck, M.M., Cell, 1997, vol. 91, pp. 5–8.

    Google Scholar 

  13. Losada, A., Hirano, M., and Hirano, T., Genes Dev., 1998, vol. 12, pp. 1986–1997.

    Google Scholar 

  14. Darwiche, N., Freeman, L.A., and Strunnikov, A., Gene, 1999, vol. 233, pp. 39–47.

    Google Scholar 

  15. Schmiesing, J.A., Bal, A.R., Jr., Gregson, H.C., Alderton, J.M., Zhou, S., and Yokomori, K., Proc. Natl. Acad. Sci. USA, 1998, vol. 95, pp. 12906–12911.

    Google Scholar 

  16. Hirano, T., Kobayashi, R., and Hirano, M., Cell, 1997, vol. 89, pp. 511–521.

    Google Scholar 

  17. Kimura, K., Rybenkov, V.V., Crisona, N.J., Hirano, T., and Cozzarelli, N.R., Cell, 1999, vol. 98, pp. 239–248.

    Google Scholar 

  18. Sutani, T., Yuasa, T., Tomonaga, T., Dohmae, N., Takio, K., and Yanagida, M., Genes Dev., 1999, vol. 13, pp. 2271–2283.

    Google Scholar 

  19. Jessberger, R., Riwar, B., Baechtold, H., and Akhmedov, A.T., EMBO. J., 1996, vol. 15, pp. 4061–4068.

    Google Scholar 

  20. Stursberg, S., Riwar, B., and Jessberger, R., Gene, 1999, vol. 228, pp. 1–12.

    Google Scholar 

  21. Chuang, P.T., Albertson, D.G., and Meyer, B.J., Cell, 1994, vol. 79, pp. 459–474.

    Google Scholar 

  22. Lieb, J.D., Albrecht, M.R., Chuang, P.-T., and Meyer, B.J., Cell, 1998, vol. 92, pp. 265–277.

    Google Scholar 

  23. Moriya, S., Tsujikawa, E., Hassan, A.K., Asai, K., Kodama, T., and Ogasawara, N., Mol. Microbiol., 1998, vol. 29, pp. 179–187.

    Google Scholar 

  24. Melby, T.E., Ciampaglio, C.N., Briscoe, G., and Erickson, H.P., J. Cell. Biol., 1998, vol. 142, pp. 1595–1604.

    Google Scholar 

  25. Hirano, M. and Hirano, T., EMBO J., 1998, vol. 17, pp. 7139–7148.

    Google Scholar 

  26. Graumann, P.L., Losick, R., and Strunnikov, A.V., J. Bacteriol., 1998, vol. 180, pp. 5749–5755.

    Google Scholar 

  27. Britton, R.A., Chi-Hong-Lin, D., and Grossman, A.D., Genes. Dev., 1998, vol. 12, pp. 1254–1259.

    Google Scholar 

  28. Pavlova, S.V., Nesterova, T.B., and Zakian, S.M., Sbornik nauchnykh trudov (Collection of Research Works), Shumnyi, V.K., Ed., Novosibirsk: Inst. of Cytology and Genetics, Siberian Division, Russ. Acad. Sci., 2000, pp. 215–223.

    Google Scholar 

  29. Zakian, S.M., Kulbakina, N.A., and Meyer, M.N., Genet. Res., 1987, vol. 50, pp. 23–27.

    Google Scholar 

  30. Murray, V., Nucleic Acids Res., 1989, vol. 17, p. 8889.

    Google Scholar 

  31. Pearson, W.R. and Lipman, D.J., Proc. Natl. Acad. Sci. USA, 1988, vol. 85, pp. 2444–2448.

    Google Scholar 

  32. Thompson, J.D., Higgins, D.G., and Gibson, T.J., Nucleic Acids Res., 1994, vol. 22, pp. 4673–4680.

    Google Scholar 

  33. Sambrook, J., Fritsch, E.F., and Maniatis, T., Molecular Cloning: A Laboratory Manual, NY: Cold Spring Harbor Lab. Press, 1989.

    Google Scholar 

  34. Lupas, A., Van Dyke, M., and Stock, J., Science, 1991, vol. 252, pp. 1162–1164.

    Google Scholar 

  35. Sosnick, T.R., Jackson, S., Wilk, R.R., Englander, W.S., and DeGrado, W.F., Proteins: Structure, Function, and Genetics, Wiley-Liss, Inc., 1996, vol. 24, pp. 427–432.

    Google Scholar 

  36. Strunnikov, A.V., Hogan, E., and Koshland, D., Genes. Dev., 1995, vol. 9, pp. 587–599.

    Google Scholar 

  37. Saitoh, N., Goldberg, I.G., Wood, E.R., and Earnshaw, W.C., J. Cell Biol., 1994, vol. 127, pp. 303–318.

    Google Scholar 

  38. Walker, J.E., Sarste, M., Runswick, M.J., and Gay, N.J., EMBO J., 1982, vol. 1, pp. 945–951.

    Google Scholar 

  39. Akhmedov, A.T., Tsai-Pflugfelder, C., Frei, M., Kemper, B., Gasser, S.M., and Jessberger, R., J. Biol. Chem., 1998, vol. 273, pp. 24088–24094.

    Google Scholar 

  40. Saka, Y., Sutani, T., Yamashita, Y., Saitoh, S., Takeuchi, M., Nakaseko, Y., and Yanagida, M., EMBO J., 1994, vol. 13, pp. 4938–4952.

    Google Scholar 

  41. Shimizu, K., Shirataki, H., Honda, T., Minami, S., and Takai, Y., J. Biol. Chem., 1998, vol. 273, pp. 6591–6594.

    Google Scholar 

  42. Rocques, P.J., Clark, J., Ball, S., Crew, J., Gill, S., Christodoulou, Z., Borts, R.H., Louis, E.J., Davies, K.E., and Cooper, C.S., Hum. Mol. Genet., 1995, vol. 4, pp. 243–249.

    Google Scholar 

  43. Klein, F., Mahr, P., Galova, M., Buonomo, S.B., Michaelis, C., Nairz, K., and Nasmyth, K., Cell, 1999, vol. 98, pp. 91–103.

    Google Scholar 

  44. Eijpe, M., Heyting, C., Gross, B., and Jessberger, R., J. Cell Sci., 2000, vol. 113, pp. 673–682.

    Google Scholar 

  45. Sutani, T., Yuasa, T., Tomonaga, T., Dohmae, N., Takio, K., and Yanagida, M., Genes Dev., 1999, vol. 13, pp. 2271–2283.

    Google Scholar 

  46. Lieb, J.D., Capowski, E.E., Meneely, P., and Meyer, B.J., Science, 1996, vol. 274, pp. 1732–1736.

    Google Scholar 

  47. Park, J-G. and Chapman, V.M., Mol. Cell. Biol., 1994, vol. 14, pp. 7975–7983.

    Google Scholar 

  48. Jeppensen, P. and Turner, B.M., Cell, 1993, vol. 74, pp. 281–289.

    Google Scholar 

  49. Clemson, C.M., McNeil, J.A., and Willard, H.F., J. Cell Biol., 1996, vol. 132, pp. 259–275.

    Google Scholar 

  50. Mermoud, J.E., Costanzi, C., Pehrson, J.R., and Brockdorff, N., J. Cell Biol., 1999, vol. 147, pp. 1399–1408.

    Google Scholar 

  51. Costanzi, C., Stein, P., Worrad, D.M., Schultz, R.M., and Pehrson, J.R., Development, 2000, vol. 127, pp. 2283–2289.

    Google Scholar 

  52. Donze, D., Adams, C.R., Rine, J., and Kamakaka, R.T., Genes Dev., 1999, vol. 13, pp. 698–708.

    Google Scholar 

  53. Sultana, R., Adler, D.A., Edelhoff, S., Carrel, L., Lee, K.H., Chapman, V.C., Willard, H.F., and Disteche, C.M., Hum. Mol. Genet., 1995, vol. 4, pp. 257–263.

    Google Scholar 

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Authors and Affiliations

  1. Siberian Division, Russian Academy of Sciences, Institute of Cytology and Genetics, Novosibirsk, 630090, Russia

    S. V. Pavlova, T. B. Nesterova & S. M. Zakian

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  1. S. V. Pavlova
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  2. T. B. Nesterova
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  3. S. M. Zakian
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Pavlova, S.V., Nesterova, T.B. & Zakian, S.M. Genes for the SMC Family Proteins in a Common Vole Microtus arvalis. Molecular Biology 35, 324–330 (2001). https://doi.org/10.1023/A:1010406308182

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