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Signal recognition particle mediated protein targeting in Escherichia coli

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Abstract

The signal recognition particle (SRP) is a conserved ribonucleoprotein complex that binds to targeting sequences in nascent secretory and membrane proteins. The SRP guides these proteins to the cytoplasmic membrane in prokaryotes and the endoplasmic reticulum membrane in eukaryotes via an interaction with its cognate receptor. The E. coli SRP is relatively small and is currently used as a model for fundamental and applied studies on translation-linked protein targeting. In this review recent advances in our understanding of the structure and function of the E. coli SRP and its receptor are discussed. In particular, the interplay between the SRP pathway and other targeting routes, the role of guanine nucleotides in cycling of the SRP and the substrate specificity of the SRP are highlighted

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  1. Quido A. Valent

    Present address: Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX Amsterdam, The Netherlands (E-mail

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  1. Department of Molecular Microbiology, Institute of Molecular Biological Sciences, BioCentrum Amsterdam, Faculty of Biology, Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081, HV Amsterdam, The Netherlands

    Quido A. Valent

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Valent, Q.A. Signal recognition particle mediated protein targeting in Escherichia coli. Antonie Van Leeuwenhoek 79, 17–31 (2001). https://doi.org/10.1023/A:1010256109582

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