Longevity Determined by Paternal Ancestors' Nutrition during Their Slow Growth Period

Abstract

Social circumstances often impinge on later generations in a socio-economic manner, giving children an uneven start in life. Overfeeding and overeating might not be an exception. The pathways might be complex but one direct mechanism could be genomic imprinting and loss of imprinting. An intergenerational "feedforward" control loop has been proposed, that links grandparental nutrition with the grandchild's growth. The mechanism has been speculated to be a specific response, e.g. to their nutritional state, directly modifying the setting of the gametic imprint on one or more genes. This study raises the question: Can overnutrition during a child's slow growth period trigger such direct mechanisms and partly determine mortality?

Data were collected by following-up a cohort born in 1905 in Överkalix parish, northernmost Sweden. The probands were characterised by their parents' or grandparents' access to food during their own slow growth period. Availability of food in the area was defined by referring to historical data on harvests and food prices, records of local community meetings and general historical facts.

If there was a surfeit of food in the environment when the paternal grandfather was a 9–12 year old boy a shortening of the proband survival could be demonstrated. The influence of parents', maternal grandparents' and paternal grandmothers' access to food during their slow growth period was discounted in a multivariable analysis. The results are indicative of very early programming mechanisms in human adaptation to the social environment.

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REFERENCES

  1. Communications from the County Governor in Västerbotten to His Majesty the King (Unprinted) Provincial Archive (Landshövdingens i Västerbottens län skrivelser till Kungl. Maj:t. Härnösands landsarkiv, Sweden)

  2. Gosden, R., J. Krapez and D. Briggs (1997). Growth and development of the mammalian oocyte. Bioessays 19: 875-82.

    Google Scholar 

  3. Hall, J.G. (1997). Genomic imprinting: nature and clinical relevance. Annual Review of Medicine 48: 35-44.

    Google Scholar 

  4. Hellstenius, J. (1871). Skördarna i Sverige och deras verkningar. [Harvests in Sweden and their repercussions]. Statistisk Tidskrift 77-119. Stockholm, Sweden.

  5. Jörberg, L. (1972). A history of prices in Sweden 1732–1914. CWK Gleerup, Lund, Sweden.

    Google Scholar 

  6. Kato, Y., W.M. Rideout 3rd, K., Hilton, S.C. Burton, Y. Tsunoda and M.A. Surani (1999). Developmental potential of mouse primordial germ cells. Development 126: 1823-32.

    Google Scholar 

  7. Lumey, L.H. and A.D. Stein (1997). Offspring birth weights after maternal intrauterine undernutrition: a comparison within sibships. American Journal of Epidemiology 146: 810-19.

    Google Scholar 

  8. Martyn, C.N., D.J. Barker and C. Osmond (1996). Mothers' pelvic size, fetal growth, and death from stroke and coronary heart disease in men in the UK. The Lancet 348: 1264-8.

    Google Scholar 

  9. McGill, H.C. Jr. (1998). Nutrition in early life and cardiovascular disease. Current Opinion in Lipidology 9: 23-7.

    Google Scholar 

  10. Pembrey, M. (1996). Imprinting and transgenerational modulation of gene expression; human growth as a model. Acta Geneticae Medicae et Genellologiae 45: 111-25

    Google Scholar 

  11. Picton, H., D. Briggs and R. Gosden (1998). The molecular basis of oocyte growth and development. Molecular and Cellular Endocrinology 145: 27-37.

    Google Scholar 

  12. Prader, A., R.H. Largo, L. Molinari and C. Issler (1989). Physical growth of Swiss children from birth to 20 years of age. First Zurich Longitudinal Study of Growth and Development. Helvetica Paediatrica Acta 43:Suppl 52: 1-125.

    Google Scholar 

  13. Signorelli L.B. and D. Trichopoulos (1998). Perinatal determinants of adult cardiovascular disease and cancer. Scandinavian Journal of Social Medicine 26: 161-5.

    Google Scholar 

  14. Smith, G.D., C. Hart, G. Watt, D. Hole and V. Hawthorne (1998). Individual social class, areabased deprivation, cardiovascular disease risk factors, and mortality: the Renfrew and Paisley Study. Journal of Epidemiology and Community Health 52: 399-405.

    Google Scholar 

  15. Tanner, J.M. (1981). A History of the Study of Human Growth. Cambridge University Press, Cambridge.

    Google Scholar 

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Bygren, L.O., Kaati, G. & Edvinsson, S. Longevity Determined by Paternal Ancestors' Nutrition during Their Slow Growth Period. Acta Biotheor 49, 53–59 (2001). https://doi.org/10.1023/A:1010241825519

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  • Genomic imprinting
  • childhood nutrition
  • off-spring