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Immunomodulatory Properties of 2-C-Methyl-D-Erythritol-2,4-Cyclopyrophosphate and the Search for Its New Derivatives

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Abstract

A strong immunomodulatory effect of 2-C-Methyl-D-erythritol-2,4-cyclopyrophosphate (MEC) responsible for the survival of bacteria was shown on isolated macrophages and in experimental infections in mice (typhoid and tularemia). Derivatives of MEC were found by 1H-NMR spectroscopy under stress conditions in colorless mutants of the bacteria and isolated to be subsequently purified and used for modulation of the immune system of animals.

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Authors and Affiliations

  1. State Research Center of Applied Microbiology, Obolensk, Moscow oblast, Russia

    V. D. Potapov, S. F. Biketov, G. M. Titareva & I. V. Bakhteeva

  2. Bach Institute of Biochemistry, Russian Academy of Sciences, Leninskii pr. 33, Moscow, 117071, Russia

    G. R. Demina, E. I. Lysak & D. N. Ostrovsky

Authors
  1. V. D. Potapov
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  2. S. F. Biketov
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  3. G. R. Demina
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  4. E. I. Lysak
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  5. G. M. Titareva
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  6. I. V. Bakhteeva
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  7. D. N. Ostrovsky
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Potapov, V.D., Biketov, S.F., Demina, G.R. et al. Immunomodulatory Properties of 2-C-Methyl-D-Erythritol-2,4-Cyclopyrophosphate and the Search for Its New Derivatives. Applied Biochemistry and Microbiology 37, 238–242 (2001). https://doi.org/10.1023/A:1010216815237

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  • DOI: https://doi.org/10.1023/A:1010216815237

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