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‘Gie Me Ae Spark O' Nature's Fire’. An Insight Into Cell Physiology From Calorimetry

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Abstract

A formal explanation of Mayer's enthalpy balance method as applied to cell physiology is given with particular reference to striated muscle tissue. The approach is then extended to animal cells growing in a bioreactor, showing its use to optimise their growth and the production of therapeutic proteins, as well as defining the correct physiological conditions. Attention is then drawn to the value of the calorimetric-respirometric ratio in defining the anaerobic pathways operating simultaneously with respiration under fully aerobic conditions. An important field now is to resolve the metabolic costs of cell signalling cascades, an area that could demonstrate the coming importance of integrated circuit calorimetry.

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  1. The Institute of Biological Sciences, Edward Llwyd Building, The University of Wales, Penglais, Aberystwyth, SY23 3DA, United Kingdom

    R. B. Kemp

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Kemp, R.B. ‘Gie Me Ae Spark O' Nature's Fire’. An Insight Into Cell Physiology From Calorimetry. Journal of Thermal Analysis and Calorimetry 60, 831–843 (2000). https://doi.org/10.1023/A:1010199422705

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