Abstract
This article provides a thermodynamic analysis of DSC data for acetaminophen polymorphic forms I and II by measurement of heat capacity. Form I is found to have lower heat capacity and free energy and hence better stability than Form II down to at least –30°C. The transition temperature below which Form II becomes more stable was determined to be less than –120°C. Form I is more stable than Form II as a consequence of its higher entropy, since its crystallographic packing arrangement is of larger energy.
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Sacchetti, M. Thermodynamic Analysis of DSC Data for Acetaminophen Polymorphs. Journal of Thermal Analysis and Calorimetry 63, 345–350 (2000). https://doi.org/10.1023/A:1010180123331
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DOI: https://doi.org/10.1023/A:1010180123331