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Bifonazole-β-cyclodextrin Inclusion Complexes. Thermal analysis and X-ray powder diffraction study

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Abstract

The complexation of bifonazole, an antimycotic hydrophobic imidazole derivative, with β-cyclodextrin (β-CD) was investigated in solid phase, using the following complementary techniques: differential scanning calorimetry (DSC), thermogravimetric analysis (TG) and X-ray powder diffractometry. The β-CD-bifonazole samples were prepared in both aqueous medium by coprecipitation and in solid state by kneading method and the β-CD-bifonazole binary diagrams were drawn. The experimental results demonstrate the formation of two binary compounds, β-CD-bifonazole and (β-CD)x bifonazole (x =2 or 4). The first compound may be an inclusion compound and the second a crystallized compound, in which the bifonazole is not necessarily included in the cyclodextrin internal cavity.

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Authors and Affiliations

  1. Laboratoire de Chimie Physique, Faculté de Médecine et de Pharmacie, Place Saint-Jacques, 25030, Besançon cedex, France

    N. Morin & J.-C. Rouland

  2. Laboratoire de Chimie Physique, Faculté de Pharmacie, 4 Avenue de l'Observatoire, 75270, Paris cedex 06, France

    A. Chilouet

  3. Laboratoire de Pharmacie Galénique, Faculté de Médecine et de Pharmacie, Place Saint Jacques, 25030, Besançon cedex, France

    J. Millet

Authors
  1. N. Morin
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  2. A. Chilouet
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  3. J. Millet
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  4. J.-C. Rouland
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Morin, N., Chilouet, A., Millet, J. et al. Bifonazole-β-cyclodextrin Inclusion Complexes. Thermal analysis and X-ray powder diffraction study. Journal of Thermal Analysis and Calorimetry 62, 187–201 (2000). https://doi.org/10.1023/A:1010127231416

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  • DOI: https://doi.org/10.1023/A:1010127231416

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