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The Thermal Stability of Ciprofloxacin Complexes with Magnesium(II), Zinc(II) and Cobalt(II)

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Abstract

The thermal behaviour of Mg(II), Zn(II) and Co(II) compounds of ciprofloxacin was studied by thermogravimetry (TG) and differential thermal analysis (DTA) in order to determine or to confirm some structural characteristics of substances. The complexes decompose in two steps: dehydration and pyrolytic decomposition of the anhydrous complexes to form metal oxide or metal fluoride. The dehydration process of one magnesium(II) compound takes place in two steps suggesting a marked difference in the bonding of water molecules. The different bonding mode of the ciprofloxacin molecules in both magnesium compounds leads to different residues of the thermal decompositions.

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References

  1. H. Koga, A. Itoh, S. Murayama, S. Suzue and T. Irikura, J. Med. Chem., 23 (1980) 1358.

    CAS  Google Scholar 

  2. B. M. Lomaestro and G. R. Bailie, Ann. Pharmacother., 25 (1991) 1249.

    CAS  Google Scholar 

  3. A. O. Okhamafe, J. O. Akerele and C. S. Chukuka, Int. J. Pharm., 68 (1991) 11.

    Article  CAS  Google Scholar 

  4. R. E. Polk, Am. J. Med., 87 (1989) 76.

    Article  Google Scholar 

  5. N. C. Baenziger, Acta Cryst. C, 42 (1986) 1505.

    Article  Google Scholar 

  6. C. Chulvi. M. C. Muñoz, L. Perelló, R. Ortiz, M. I. Arriortua, J. Via, K. Urtiaga, J. M. Amigó and L. E. Ochando, J. Inorg. Biochem., 42 (1991) 133.

    Article  CAS  Google Scholar 

  7. G. M. Diaz, L. M. R. Martinez-Aquilera and R. P. Alfonso, Inorg. Chim. Acta, 138 (1987) 41.

    Article  Google Scholar 

  8. P. B. Issopoulos, Acta Pharm. Yugosl., 39 (1988) 267.

    Google Scholar 

  9. M. Ruiz, R. Ortiz and L. Parello, Inorg. Chimica Acta, 217 (1994) 149.

    Article  CAS  Google Scholar 

  10. G. M. Diaz and J. Ireta-Moreno, J. Inorg. Biochem., 54 (1994) 235.

    Article  Google Scholar 

  11. I. Turel, I. Leban, M. Zupančič, P. Bukovec and K. Gruber, Acta Cryst. C, 52 (1996) 2443.

    Article  Google Scholar 

  12. F. Gao, P. Yang, J. Xie and H. Wang, J. Inorg. Biochem., 60 (1995) 61.

    Article  CAS  Google Scholar 

  13. I. Turel, K. Gruber, I. Leban and N. Bukovec, J. Inorg. Biochem., 61 (1996) 197.

    Article  CAS  Google Scholar 

  14. S. C. Wallis, L. R. Gahan, B. G. Charles, T. W. Hambley and P. A. Duckworth, J. Inorg. Biochem., 62 (1996) 1.

    Article  CAS  Google Scholar 

  15. I. Turel, N. Bukovec and E. Farkas, Polyhedron, 15 (1996) 269.

    Article  CAS  Google Scholar 

  16. I. Turel and P. Bukovec, Thermochim. Acta, 287 (1996) 311.

    Article  CAS  Google Scholar 

  17. I. Turel, I. Leban, G. Klintschar, N. Bukovec and S. Zaral, J. Inorg. Biochem., 66 (1997) 77.

    Article  CAS  Google Scholar 

  18. I. Turel, I. Leban and N. Bukovec, J. Inorg. Biochem., 66 (1997) 241.

    Article  CAS  Google Scholar 

  19. G. Mendoza-Diaz, R. Perez-Alonso and R. Moreno-Esparza, J. Inorg. Biochem., 64 (1996) 207.

    Article  CAS  Google Scholar 

  20. M. Ruiz, L. Perelló, R. Ortiz, A. Castiñeiras, C. Maichle-Mössmer and E. Cantón, J. Inorg. Biochem., 59 (1995) 801.

    Article  CAS  Google Scholar 

  21. I. Turel, A. Šonc, M. Zupančič, K. Sepčič and T. Turk, Metal-Based Drugs, 7 (2000) 101.

    CAS  Google Scholar 

  22. S. E. Castillo-Blum and E. Barba-Behrens, Coord. Chem. Rev., 196 (2000) 3.

    Article  CAS  Google Scholar 

  23. M. Zupančič and P. Bukovec, Acta Pharm., 46 (1996) 221.

    Google Scholar 

  24. M. Zupančič, I. Turel, P. Bukovec, A. J. P. White and D. J. Williams, submitted for publication in Croatia Chemica Acta.

  25. Fachinformationszentrum Karlsruhe, Inorganic Crystal Structure Database, FIZ Karlsruhe and Gmelin-Institut 1990, release 1999.

  26. F. A. Cotton and G. Wilkinson, Advanced Inorganic Chemistry, John Wiley and Sons, New York, 5th edition, 1988, Chap. 16.

    Google Scholar 

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Authors and Affiliations

  1. Faculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva 5, SI-1000, Ljubljana, Slovenia

    M. Zupančič, R. Cerc Korošec & P. Bukovec

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  1. M. Zupančič
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  2. R. Cerc Korošec
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  3. P. Bukovec
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Zupančič, M., Cerc Korošec, R. & Bukovec, P. The Thermal Stability of Ciprofloxacin Complexes with Magnesium(II), Zinc(II) and Cobalt(II). Journal of Thermal Analysis and Calorimetry 63, 787–795 (2001). https://doi.org/10.1023/A:1010100423044

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  • DOI: https://doi.org/10.1023/A:1010100423044

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