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Molecular Diagnostic Tests in the Diagnosis and Management of Thyroid Carcinoma

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References

  1. Ho DD, Mougdil T, Alam M. Quantitation of human immunodeficiency virus type I in the blood of infected persons. N Engl J Med 1989;321:1621-1625.

    Google Scholar 

  2. Coombs RW, Collier AC, Allain J-P, et al. Plasma viremia in human immunodeficiency virus infection. N Engl J Med 1989;321:1626-1631.

    Google Scholar 

  3. Smith B, Selby P, Southgate J, et al. Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reaction. Lancet 1991;338:1227-1229.

    Google Scholar 

  4. Moreno JG, Croce CM, Fischer R, et al. Detection of hematogenous micrometastases in patients with prostate cancer. Cancer Res 1992;52:6110-6112.

    Google Scholar 

  5. Smanik P, Liu Q, Furminger TL, et al. Cloning of the human sodium iodide symporter. Biochem Biophys Res Comm 1996;226:339-345.

    Google Scholar 

  6. Peele ME, Carr FE, Baker JR, Jr, Wartofsky L, Burman KD. TSH beta subunit gene expression in human lymphocytes. Am J Med Sci 1993;305:1-7.

    Google Scholar 

  7. Sarker G, Sommer SS. Access to messenger RNA sequences or its protein product is not limited by tissue or species specificity. Science 1988;244:331-334.

    Google Scholar 

  8. Freeman WM, Walker SJ, Vrana KE. Quantitative RT-PCR Pitfalls and potential. Bio Techniques 1999;26:112-125.

    Google Scholar 

  9. Gharib H, Goellner JR. Fine-needle aspiration biopsy of the thyroid, An appraisal. Ann Intern Med 1993;118:282.

    Google Scholar 

  10. Haugen BR, Nawaz S, Markham N, Hashizumi T, Shroyer AL, Werness B, Shroyer KR. Telomerase activity in benign and malignant thyroid tumors. Thyroid 1997;7:337.

    Google Scholar 

  11. Singer PA, Cooper DS, Daniels GH, et al. Treatment guidelines for patients with thyroid nodules and well-differentiated thyroid cancer. Arch Int Med 1996;156:2165-2172.

    Google Scholar 

  12. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266:2011-2015.

    Google Scholar 

  13. Nakayama J, Tahara H, Tahara E, Saito M, Ito K, Nakamura H, Nakanishi T, Tahara E, Ide T, Ishikawa F. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet 1998;18:65.

    Google Scholar 

  14. Yashima K, Milchgrub S, Gollahon LS, Maitra A, Saboorian MH, Shay JW, Gazdar AF. Telomerase enzyme activity and RNA expression during the multistage pathogenesis of breast carcinoma. Clin Cancer Res 1998;4:229.

    Google Scholar 

  15. Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, Caddle SD, Ziaugra L, Beijersbergen RL, Davidoff MJ, Liu Q, Bacchetti S, Haber DA, Weinberg RA. HEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 1997;90:785.

    Google Scholar 

  16. Harrington L, McPhail T, Mar V, Zhou W, Oulton R, Bass MB, Arruda I, Robinson MO. A mammalian telomerase-associated protein. Science 1997;275:973.

    Google Scholar 

  17. Nakayama J, Saito M, Nakamura H, Matsuura A, Ishikawa F. TLP1 a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell 1997;88:875.

    Google Scholar 

  18. Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, Adams RR, Chang E, Allsopp RC, Yu J, Le S, West MD, Harley CB, Andrews WH, Greider CW, Villeponteau B. The RNA component of human telomerase. Science 1995;269:1236.

    Google Scholar 

  19. Piatyszek MA, NWK, Weinrich SL, Hiyama K, Hiyama E, Wright WE, Shay JW. Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP). Methods in Cell Sci 1995;17:1.

    Google Scholar 

  20. Ohyashiki K, Ohyashiki JH, Nishimaki J, Toyama K, Ebihara Y, Kato H, Wright WE, Shay JW. Cytological detection of telomerase activity using an in situ telomeric repeat ampli®cation protocol assay. Cancer Res 1997;57:2100.

    Google Scholar 

  21. Yashima K, Vuitch F, Gazdar AF, Fahey T, Jr. Telomerase activity in benign and malignant thyroid diseases. Surgery 1997;122:1141.

    Google Scholar 

  22. Brousset P, Chaouche N, Leprat F, Branet-Brousset F, Trouette H, Zenou RC, Merlio JP, Delsol G. Telomerase activity in human thyroid carcinomas originating from the follicular cells. J Clin Endocrinol Metab 1997;82:4214.

    Google Scholar 

  23. Okayasu I, Osakabe T, Fujiwara M, Fukuda H, Kato M, Oshimura M. Significant correlation of telomerase activity in thyroid papillary carcinomas with cell differentiation, proliferation and extrathyroidal extension. Jpn J Cancer Res 1997;88:965.

    Google Scholar 

  24. Cheng AJ, Lin JD, Chan T, Wang TC. Telomerase activity in benign and malignant thyroid tissues. Br J Cancer 1998;77:2177-2180.

    Google Scholar 

  25. Onada N, Ishikawa T, Yoshikawa K, et al. Telomerase activity in thyroid tumors. Oncol Rep 1998;5:1447-1450.

    Google Scholar 

  26. Umbricht CB, Saji M, Westra WH, Udelsman R, Zeiger MA, Sukumar S. Telomerase activity a marker to distinguish follicular thyroid adenoma from carcinoma. Cancer Res 1997;57:2144-2147.

    Google Scholar 

  27. Saji M, Westra WH, Chen H, Umbricht CB, Tuttle RM, Box MF, Udelsman R, Sukumar S, Zeiger MA. Telomerase activity in the differential diagnosis of papillary carcinoma of the thyroid. Surgery 1997;122:1137.

    Google Scholar 

  28. Saji M, Xydas S, Westra WS, et al. Human telomerase reverse transcriptase (hTERT) gene expression in thyroid neoplasms. Clin Cancer Res 1999;5:1483-1489.

    Google Scholar 

  29. Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 1995;14:4240.

    Google Scholar 

  30. Fernandez PL, Marino MJ, Gomez M, et al. Galectin-3 and laminin expression in neoplastic and non-neoplastic thyroid tissue. J Pathol 1997;181:80-86.

    Google Scholar 

  31. Xu XC, el-Naggar AK, Lotan R. Differential expression of galectin-1 and galectin-3 in thyroid tumors Potential diagnostic implications. Am J Pathol 1995;147:815-822.

    Google Scholar 

  32. Inohara H, Honjo Y, Yoshii T, et al. Expression of galectin-3 in fineneedle aspirated as a diagnostic marker differentiating benign from malignant thyroid neoplasms. Cancer 1999;85:2475-2484.

    Google Scholar 

  33. Orlandi F, Saggiorato E, Pivano G, et al. Galectin-3 is a presurgical marker of human thyroid carcinoma. Cancer Res 1998;58:3015-3020.

    Google Scholar 

  34. Bandiera A, Bonifacio D, Man®oletti G, et al. Expression of HMGI(Y) proteins in squamous intraepithelial and invasive lesions of the uterine cervix. Cancer Res 1998;58:426-431.

    Google Scholar 

  35. Chiappetta G, Tallini G, De Biasio MC, et al. Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors HMGI(Y) expression represents a potential diagnostic indicator of carcinoma. Cancer Res 1998;58:4193-4198.

    Google Scholar 

  36. Takano T, Miyauchi A, Yokozawa T, et al. Accurate and objective preoperative diagnosis of thyroid papillary carcinOomas by reverse transcription-PCR detection of oncofetal fibronectin messenger RNA in fine-needle aspiration biopsies. Cancer Res 1998;58:4913-4917.

    Google Scholar 

  37. Takano T, Matsuzuka F, Miyauchi A, et al. Restricted expression of oncofetal fibronectin mRNA in thyroid papillary and anaplastic carcinoma an in situ hybridization study. Br J Cancer 1998;78:221–224.

    Google Scholar 

  38. Haber RS, Weiser KR, Pritsker A, Reder I, Burstein DE. GLUT1 glucose transporter expression in benign and malignant thyroid nodules. Thyroid 1997;7:363-367.

    Google Scholar 

  39. Tuccari G, Barresi G. Immunohistochemical demonstration of ceruloplasmin in follicular adenomas and thyroid carcinomas. Histopathology 1987;11:723-731.

    Google Scholar 

  40. Vardeeswar P, Pandit AA, Khilnani PH, Powar HS. Differentiation of follicular adenoma and carcinoma of thyroid by immunohistochemical demonstration of ceruloplasmin. Indian J Pathol Microbiol 1994;37:165-169.

    Google Scholar 

  41. De Micco C, Zoro P, Garcia S, et al. Thyroid peroxidase immunodetection as a tool to assist diagnosis of thyroid nodules on fine-needle aspiration biospy. Eur J Endocrinol 1994;131:474-479.

    Google Scholar 

  42. Yamashita H, Noguchi S, Murakami N, Adachi M, Maruta J. Immunohistological differentiation of benign thyroid follicular cell tumors from malignant ones usefulness of antiperoxidase and JT-95 antibodies. Acta Pathol Jpn 1993;43:670-673.

    Google Scholar 

  43. de Nigirs F, Visconti R, Carutti J, et al. Overexpression of the HIP gene coding for a heparin/heparin sulfate-binding protein in human thyroid carcinomas. Cancer Res 1998;58:4745-4751.

    Google Scholar 

  44. Schelfhout LJ, Van Muijen GN, Fleuren GJ. Expression of keratin 19 distinguishes papillary thyroid carcinomas from follicular carcinomas and follicular thyroid adenoma. Am J Clin Pathol 1989;92:654–658.

    Google Scholar 

  45. Erickson LA, Jin L, Wollan PC, Thompson GB, van Heerden J, Lloyd RV. Expression of p27kipl and K1-67 in benign and malignant thyroid tumors. Mod Pathol 1998;11:169-174.

    Google Scholar 

  46. Kotani T, Aatake Y, Ogat Y, et al. Expression of dipeptidyl aminopeptidase IV activity in thyroid carcinoma. Cancer Lett 1991;57:203-208.

    Google Scholar 

  47. Miettinhen M, Karkkainen P. Differential reactivity of HBME-1 and CD15 antibodies in benign and malignant thyroid tumours, Preferential reactivity with malignant tumours. Virchows Arch 1996;429:213–219.

    Google Scholar 

  48. Kruger W, Krzizanowski C, Holweg M, et al. Reverse transcriptase/ polymerase chain reaction detection of cytokeratin-19 mRNA in bone marrow and blood of breast cancer patients. J Cancer Res Clin Oncol 1996;122:679-686.

    Google Scholar 

  49. Corey E, Arfman EW, Liu AY, Vessella RL. Improved reverse transcriptase-polymerase chain reaction protocol with exogenous internal competitive control for prostate-specific antigen mRNA in blood and bone marrow. Clin Chem 1997;43:443–452.

    Google Scholar 

  50. Arturi F, Russo D, Giuffrida D, Ippolito A, Perroti N, Vigneri R, Filetti S. Early diagnosis by genetic analysis of differentiated thyroid cancer metastases in small lymph nodes. J Clin Endocrinol Metab 1997;82:1638-1641.

    Google Scholar 

  51. Ghossein RA, Scher HI, Gerald WL, et al. Detection of circulating tumor cells in patients with localized and metastatic prostatic carcinoma clinical implications. J Clin Oncol 1995;13:1195-1200.

    Google Scholar 

  52. Ringel MD, Ladenson PW, Levine MA. Molecular diagnosis of residual or recurrent thyroid cancer by ampli®cation of thyroglobulin mRNA in peripheral blood. J Clin Endocrinol Metab 1998;83:4435–4442.

    Google Scholar 

  53. Brandt B, Junker R, Griwatz C, et al. Isolation of prostate-derived single cells and cell clusters from human peripheral blood. Cancer Res 1996;56:4556-4561.

    Google Scholar 

  54. Racila E, Euhus D, Weiss AJ, et al. Detection and characterization of carcinoma cells in the blood. Proc Natl Acad Sci, USA 1998;95:4589-4594.

    Google Scholar 

  55. Mazzaferri EL, Jhiang SM. Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med 1994;97:418-428.

    Google Scholar 

  56. Hay I. Papillary thyroid carcinoma. Endocrinol Metab Clin North Am 1990;19:545-576.

    Google Scholar 

  57. Hundahl SA, Fleming ID, Fremgem AM, Menck HR. A national cancer data base report on 53,856 cases of thyroid carcinoma treated in the U.S, 1985-1995. Cancer 1998;83:2638-2648.

    Google Scholar 

  58. Farthmann B, Eberle J, Krasagakis K, et al. RT-PCR for Tyrosinase-mRNA-Positive cells in peripheral blood evaluation strategy and correlation with known prognostic markers in 123melanoma patients. J Invest Dermatol 1998;3:263-267.

    Google Scholar 

  59. Ghossein RA, Coit D, Brennan M, et al. Prognostic significance of peripheral blood and bone marrow tyrosinase messenger RNA in malignant melanoma. Clin Cancer Res 1998;4:419–428.

    Google Scholar 

  60. Spencer CA, Wang CC. Thyroglobulin measurement techniques, clinical benefits and pitfalls. Endocrinol Metab Clin North Am 1996;24:841–864.

    Google Scholar 

  61. Ditkoff BA, Marvin MR, Yemul S, Shi YJ, Chabot J, Feind C, Gerfo PL. Detection of circulating thyroid cells in peripheral blood. Surgery 1996;120:959–965.

    Google Scholar 

  62. Tallini G, Ghossein R, Emanuel J, et al. Detection of thyroglobulin, thyroid peroxidase, and RET/PTC1 mRNA transcripts in the peripheral blood of patients with thyroid disease. J Clin Oncol 1998;16:1158–1166.

    Google Scholar 

  63. Wingo S, Ringel MD, Anderson JS, et al. Quantitative RT-PCR measurement of thyroglobulin mRNA in peripheral blood of normal subjects. Clin Chem 1999;27:2578–2582.

    Google Scholar 

  64. Ringel MD, Balducci-Silano PL, Anderson JS, et al. Quantitative RT-PCR of thyroglobulin messenger RNA for detection of recurrent or residual thyroid cancer. J Clin Endocrinol Metab 1999;84:4037-4042.

    Google Scholar 

  65. Kelman AS, Pritsker A, Davies TF, Haber RS. A New Quantitative ELISA-Based PCR Assay for Thyroglobulin mRNA in the Blood of Thyroid Cancer Patients. 1998, 71st Annual Meeting of the American Thyroid Association, [Abstract].

  66. Ringel MD, Balducci-Siliano PL, Tuttle RM, et al. Quantitative Thyroglobulin and NIS RT-PCR Detection of Recurrent or Residual Thyroid Carcinoma in Patients with Anti-Thyroglobulin Antibodies. 1998, 71st Annual Meeting of the American Thyroid Association, [Abstract].

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  1. Section of Endocrinology, Washington Hospital Center, Washington, DC

    Matthew D. Ringel

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Ringel, M.D. Molecular Diagnostic Tests in the Diagnosis and Management of Thyroid Carcinoma. Rev Endocr Metab Disord 1, 173–181 (2000). https://doi.org/10.1023/A:1010027014324

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