Skip to main content
Log in

Digoxin and Cardiac Arrhythmias: An Update

  • Published:
Cardiac Electrophysiology Review

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Schatzmann HJ. atHerzglykoside als Hemmstofe fuer den aktiven Kalium und Natriumtransport durch die Erythrocytenmembran. Helv Physiol Pharmacol Acta 1953;11:346-354.

    Google Scholar 

  2. Lee CO, Dagostino M. Effect of strophanthidin on intracellular Na ion activity and twitch tension of constantly driven canine cardiac Purkinje fibers. Biophys J 1982;40:185-198.

    Google Scholar 

  3. Verdonck F, Vanhaecke J, Mubagwa K, Flameng W, Stankovicova T, Sipido K. Sensitivity of the Na+/K+ pump current to cardiac glycosides in ventricular myocytes from human failing heart. Biophys J 1998;74:A354.

    Google Scholar 

  4. Santana LF, Gomez AM, Lederer WJ. Ca2+ flux through promiscuous cardiac Na+ channels: Slip-mode conductance. Science 1998;279:1027-1033.

    Google Scholar 

  5. Rosen MR, Gelband H, Merker C, Hoffman BF. Mechanisms of digoxin toxicity: Effects of ouabain on phase 4 of canine Purkinje fibers transmembrane potentials. Circ Res 1973;47: 681-689.

    Google Scholar 

  6. Smith TW. Digitalis: Mechanisms of action and clinical use. N Engl J Med 1988;318:356-358.

    Google Scholar 

  7. Sarter BH, Marchlinski FE. Redefining the role of digoxin in the treatment of atrial fibrillation. Am J Cardiol 1992;69: 71G-81G.

    Google Scholar 

  8. Beasley R, Smith DA, McHaffie DJ. Exercise heart rates at different serum digoxin concentration in patients with atrial fibrillation. Br Med J 1985;290:9-11.

    Google Scholar 

  9. David D, Segni ED, Klein HO, Kaplinsky E. Inefficacy of digitalis in the control of heart rate in patients with chronic atrial fibrillation: beneficial effect of an added beta adrenergic blocking agent. Am J Cardiol 1979;44:1378-1382.

    Google Scholar 

  10. Steinberg JS, Katz RJ, Bren GB, Buff LA, Varghese PJ. Efficacy of oral diltiazem to control ventricular response in chronic atrial fibrillation at rest and during exercise. J Am Coll Cardiol 1987;9:405-411.

    Google Scholar 

  11. Falk RH, Knowlton AA, Bernard SA, Gotlieb NE, Battinelli NJ. Digoxin for converting recent-onset atrial fibrillation to sinus rhythm. Arandomised double-blind trial. Ann Int Med 1987;106:503-506.

    Google Scholar 

  12. The Digitalis in Acute Atrial Fibrillation [DAAF] Trial Group. Intravenous digoxin in acute atrial fibrillation: Results of a randomized, placebo-controlled multicentre trial in 239 patients. Eur Heart J 1997;18:649-654.

    Google Scholar 

  13. Schreck DM, Rivera AR, Tricarico VJ. Emergency management of atrial fibrillation and flutter: intravenous diltiazem versus intravenous digoxin. Ann Emerg Med 1997;29:135-140.

    Google Scholar 

  14. The Esmolol vs Placebo Multicenter Study Group. Comparison of the efficacy and safety of esmolol, a short-acting beta blocker, with placebo in the treatment of supraventricular tachyarrhythmias. Am Heart J 1986;111:42-48.

    Google Scholar 

  15. Innes GD, Vertesi L, Dillon EC, Metcalfe C. Effectiveness of verapamil-quinidine versus digoxin-quinidine in the emergency department treatment of paroxysmal atrial fibrillation. Ann Emerg Med 1997;29:126-134.

    Google Scholar 

  16. Goldenberg IF, Lewis WR, Dias VC, Heywood JT, Pederson WR. Intravenous diltiazem for the treatment of patients with atrial fibrillation or flutter and moderate to severe congestive heart failure. Am J Cardiol 1994;74:884-889.

    Google Scholar 

  17. Shettigar UR, Toole JG, Appunn DO. Combined use of esmolol and digoxin in the acute treatment of atrial fibrillation or flutter. Am Heart J 1993;126:368-374.

    Google Scholar 

  18. Rawles JM, Metcalfe MJ, Jennings K. Time of occurrence, duration and ventricular rate of paroxysmal atrial fibrillation: the effect of digoxin. Br Heart J 1990;63:225-227.

    Google Scholar 

  19. Andrews TC, Reimold SC, Berlin JA, Antman EM. Prevention of supraventricular arrhythmias after coronary artery bypass surgery: A meta-analysis of randomized control trials. Circulation 1991;84(Suppl III):III-236-III-244.

    Google Scholar 

  20. Rithcie AJ, Bowe P, Gibbons JR. Prophylactic digitalization for thoracotomy: A reassessment. Ann Thorac Surg 1990; 50:86-88.

    Google Scholar 

  21. Kowey PR, Dalessandro DA, Herbertson R, Briggs B, Wertan MAC, Rials SJ, Filart RA, Marinchak RA. Effectiveness of digitalis with and without acebutolol in preventing atrial arrhythmias after coronary artery surgery. Am J Cardiol 1997;79:1114-1117.

    Google Scholar 

  22. Sellers TD Jr, Bashore TM, Gallagher JJ. Digitalis in the preexcitation syndrome. Analysis during atrial fibrillation. Circulation 1977;56:260-267.

    Google Scholar 

  23. Villian E, Vetter VL, Garcia JN, Herre J, Cifarelli A, Garson A Jr. Evolving concepts in the management of congenital junctional ectopic tachycardia. A multicenter study. Circulation 1990;81:1544-1549.

    Google Scholar 

  24. Lown B, Krieger R, Williams J. Cardioversion and digitalis drugs: Changed threshold to electric shock in digitalized animals. Circ Res 1965;17:519.

    Google Scholar 

  25. Ditchey RV, Curtis GP. Effects of apparently nontoxic doses of digoxin on ventricular ectopy after direct-current electrical shocks in dogs. J Pharmacol Exp Ther 1981;218: 212-216.

    Google Scholar 

  26. Roden D. Antiarrhythmic drugs. In: Goodman & Gilman's The Pharmacological Basis of Therapeutics. New York: McGraw-Hill, 1996;839-874.

    Google Scholar 

  27. Beller GA, Smith TW, Abelmann WH, Haber E, Hood WB Jr. Digitalis intoxication: A prospective clinical study with serum level correlations. N Engl J Med 1971;284:989-997.

    Google Scholar 

  28. Wenger TL, Butler VP Jr, Haber E, Smith TW. Treatment of 63 severely digitalis-toxic patients with digoxin-specific antibody fragments. J Am Coll Cardiol 1985;5:118A-123A.

    Google Scholar 

  29. Lynch JJ, Montgomery DG, Lucchesi BR. Facilitation of lethal ventricular arrhythmia by therapeutic digoxin in conscious post infarction dogs. Am Heart J 1986;111:883-890.

    Google Scholar 

  30. Leor J, Goldbourt U, Behar S. Is it safe to prescribe digoxin after acute myocardial infarction? Update on continued controversy. Am Heart J 1995;130:1322-1326.

    Google Scholar 

  31. The Digitalis Investigation Group. The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med 1997;336:525-533.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mazur, A., Anderson, M.E. Digoxin and Cardiac Arrhythmias: An Update. Card Electrophysiol Rev 2, 222–224 (1998). https://doi.org/10.1023/A:1009948604316

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1009948604316

Keywords

Navigation