Abstract
For successful size separation in biomedical applications, the filter used must meet several strict criteria. Not only must it have precisely-machined sub-100 nm pores (<5% variation), but it must also be able to handle large and small volumes with very high reduction ratios (>104). In this paper, we will present a bulk-micromachined, direct-bonded silicon nanofilter that can remove particles as small as 44 nm. In doing so, we will describe the fabrication, the gas and liquid characterization, and the filtrations studies done on 44 nm and 100 nm beads.
Similar content being viewed by others
References
J.P. Brody, T.D. Osborn, F.K. Forster, and P. Yager, 8th International Conference on Solid-state sensors and Actuators and Eurosensors IX (Stockholm, Sweden, 1995) p. 779.
W. Chu, T. Huen, J. Tu, and M. Ferrari, Proceedings of the SPIE 2978, 111 (1996).
T.A. Desai, W.H. Chu, J.K. Tu, G.M. Beattie, A. Hayek, and M. Ferrari, Biotechnology and Bioengineering 57, 118 (1998).
M. Ferrari, W.-H. Chu, T. Desai, D. Hansford, T. Huen, G. Mazzoni, and M. Zhang, Materials Research Society Proceedings 414, 101 (1996).
G. Kittilsand, G. Stemme, and B. Norden, Sensors and Actuators A A21–A23, 904 (1990).
H.K. Lonsdale, Journal of Membrane Science 10, 81 (1982).
A. Reisman, M. Berkenblit, S.A. Chan, F.B. Kaufman, and D.C. Green, Journal of the Electrochemical Society 126, 1406 (1979).
J.K. Tu, T. Huen, R. Szema, and M. Ferrari, Proceedings of the SPIE 3258, 148 (1998).
C.J.M. van Rijn and M.C. Elwenspoek, Proceedings of the 8th Workshop on Micro Electro Mechanical Systems (Amsterdam, The Netherlands, 1995), p. 83.
X. Yang, J.M. Yang, X.Q. Wang, E. Meng, Y.C. Tai, and C.M. Ho, Proceedings of the 11th Workshop on Micro Electro Mechanical Systems (Heidelberg, Germany, 1998).
M. Zhang and M. Ferrari, Biotechnology and Bioengineering 56, 618 (1997).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tu, J.K., Huen, T., Szema, R. et al. Filtration of Sub-100 nm Particles Using a Bulk-Micromachined, Direct-Bonded Silicon Filter. Biomedical Microdevices 1, 113–119 (1999). https://doi.org/10.1023/A:1009944423778
Issue Date:
DOI: https://doi.org/10.1023/A:1009944423778