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Cushing's Syndrome: Historical Aspects

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Abstract

A brief overview of the most important steps leading to our present knowledge of hypercorticism is given. The adrenals were described in 1563 and the pituitary had been known since Antiquity. Until Addison's description of adrenal insufficiency in 1855 virtually nothing was known of their function. Cushing in 1912 described his famous patient with hypercorticism but assumed it to be a polyglandular disorder. For almost 40 years the etiology was disputed, though Bauer early had postulated that hypercorticism ultimately reflected adrenal hyperfunction, either primarily or secondarily. Though Krause, Schloffer, Cushing, Hirsch and others early in the 20th century had introduced pituitary surgery, it was not until 1933 that the first patient with Cushing's disease had neurosurgery performed. This therapy did not gain wide acceptance until Gidot & Thibaut and Hardy pioneered transsphenoidal surgery. Adrenal surgery was for many years the treatment of hypercorticism but prior to the availability of glucocorticosteroids substitution an extremely perilous undertaking.

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References

  1. Bartholin T. Bartholinus anatomy in four books and four manuals. N Culpepper, ed. London, 1668

  2. Winslow JB. An anatomical exposition of the structure of the human body. London, 1733.

  3. Coxe JR.On the function of the capsuleÿ renales. Am J Med Sci 18276:40–49.

  4. v. Sömmering ST. Lehre von der Eingeweiden und Sinnesorganen des menschlichen Körpers. E Huschke, ed. Leipzig, 1845.

  5. Addison T. On the constitution and local effects of disease of the suprarenal capsules. London, 1855.

  6. Brown-Séquard ME. Recherches experimentales sur la physiologie et la pathologie des capsules surrénales. Acad Sci Paris 1856;43:422–425.

    Google Scholar 

  7. Shumacker HB. The early history of the adrenal glands. Bull Instit Hist Med 1936;4:39–46.

    Google Scholar 

  8. Ingall JRF. Glandulae renibus imcumbentes. Surgery 1965; 57:331–333.

    Google Scholar 

  9. Schneider CV. Dissertatio de osse cribriformi. Wittenberg, 1655.

  10. Ascher B. Ñber die Funktion der Hypophyse. Pflüger's Arch gesamm Physiol 1912:146:1–46.

    Google Scholar 

  11. Schaefer EA, Hering PT. The action of pituitary extracts upon the kidney. Philos Trans R Soc London, Series B. 1908;199:1–29.

    Google Scholar 

  12. Fritsche CF, Klebs E. Ein Beitrag zur Pathologie des Riesenwuchses. Vogel, Leipzig, 1884.

    Google Scholar 

  13. Cunningham ED. A large sub-arachnoid cyst involving the greater part of the parietal lobe of the brain. J Anat Physiol 1879;13:508–517.

    Google Scholar 

  14. Landolt AM, Zachmann M. The Irish giant: new observations concerning the nature of his ailment. Lancet 1980;1: 1311–1312.

    Google Scholar 

  15. Harris GW. Humours and hormones. J Endocrinol 1972; 53:2–23.

    Google Scholar 

  16. Bulloch W, Sequeira JH. On the relation of the suprarenal capsules to the sexual organs. Transact Path Soc London 1905;56:189–208.

    Google Scholar 

  17. Guthrie L, Emery WE. Precocious obesity, premature sexual and physical development, and hirsuties in relation to hypernephroma and other morbid conditions. Transact Clin Soc Lond 1907;40:175–202.

    Google Scholar 

  18. Cushing H. The pituitary body and its disorders. Philadelphia & London: Lippincott Comp., 1912.

    Google Scholar 

  19. Cushing H. Surgical experiences with pituitary disorders. J Am Med Assn 1914;63:1515–1525.

    Google Scholar 

  20. Cushing H. The basophilic adenomas of the pituitary body and their clinical manifestations (pituitary basophilism). Bull Johns Hopkins Hosp 1932;50:137–195.

    Google Scholar 

  21. Carney JA. The search for Harvey Cushing's patient, Minnie G., and the cause of her hypercortisolism. Am J Surg Pathol 1995;19:100–108.

    Google Scholar 

  22. Young WF Jr, Carney JA, Musa BU, Wulffstraat NM, Lens JW, Drexhage HA. Familial Cushing's syndrome due to primary pigmented nodular adrenocortical disease. Reinvestigation 50 years later. N Engl J Med 1989;321:1659–1664.

    Google Scholar 

  23. Turney HG. Discussion on disease of the pituitary body. Proc Roy Soc Med 1913;6:69–78.

    Google Scholar 

  24. Anderson J. A case of polyglandular syndrome with adrenal hypernephroma. Glasgow Med J 1915;83:178–192.

    Google Scholar 

  25. Reichman V. Ñber ein ungewöhlisches Krankheitsbild bei Hypophysenadenom. Dtsch Arch klin Med 1919;130:133–150.

    Google Scholar 

  26. Parkes Weber F. Cutaneous striae, purpura, high blood pressure, amenorrhoea and obesity, of the type sometimes connected with cortical tumours of the adrenal glands, occurring in the absence of any such tumour-with some remarks on the morphogenetic and hormonic effects of true hypernephromata of the adrenal cortex. Brit J Dermatol 1926;38:1–19.

    Google Scholar 

  27. Christy NP. Cushing's syndrome: the natural disease. In: Christy NP, ed. The Human Adrenal Cortex. New York: Harper & Row, 1971, 360–364.

    Google Scholar 

  28. Cushing H. Further notes on pituitary basophilism. JAMA 1932;99:281–284.

    Google Scholar 

  29. Cushing H. Dyspituitarism: twenty years later; with special consideration of the pituitary adenomas. Arch Intern Med 1933;51:487–557.

    Google Scholar 

  30. Thompson KW, Cushing H. Experimental pituitary basophilism. Proc Roy Soc Lond (Series B) 1932;115:88–100.

    Google Scholar 

  31. Cushing H. Posterior pituitary activity from an anatomical standpoint. Am J Path 1933;9:539–547.

    Google Scholar 

  32. Oppenheimer BS, Fishberg Am. The association of hypertension with suprarenal tumors. Arch Intern Med 1924;34:631–644.

    Google Scholar 

  33. Bishop PMF, Close HG. A case of basophil adenoma of the anterior lobe of the pituitary: “Cushing's syndrome”. Guy's Hosp Rep 1932;82:143–153.

    Google Scholar 

  34. Bauer J. Ñberfunktion des gesamten Nervensystems ohne anatomischen Befund. Wien klin Wschr 1930;43:582–586.

    Google Scholar 

  35. Medvei CV, Wermer P. Zur Differentialdiagnose des basophilen Adenoms der Hypophyse. Medizin Klinik 1934;2: 992–994.

    Google Scholar 

  36. Evans HM, Long JA. Characteristic effects upon growth, oestrus, and ovulation induced by the intraperitoneal administration of fresh anterior hypophyseal substance. Proc Nat Acad Sci 1922;8:38–39.

    Google Scholar 

  37. Collip JB, Anderson E, Thomson DL. The adrenotropic hormone of the anterior pituitary lobe. Lancet 1933;2:347–348.

    Google Scholar 

  38. Li CH, Simpson ME, Evans HM. Adrenocorticotropic hormone. J Biol Chem 1943;149:413–424.

    Google Scholar 

  39. Sayers G, White A, Long CNH. Preparation and properties of pituitary adrenocorticotropic hormone. J Biol Chem 1943; 149:425–436.

    Google Scholar 

  40. Jores A. Ñber Hormonuntersuchungen bei Morbus Cushing. Klin Wochensch 1935;14:1348–1352.

    Google Scholar 

  41. Crooke AC. A change in the basophilic cells of the pituitary gland common to conditions which exhibit the syndrome attributed to the basophilic adenoma. J Pathol Bacteriol 1935;41:339–349.

    Google Scholar 

  42. Albright F. Cushing's syndrome: its pathology and physiology, its relationship to the adreno-genital syndrome, and its connection with the problem of the reaction of the body to injurious agents. Harvey Lectures 1942–43 1943;38:123–186.

    Google Scholar 

  43. Kepler EJ. Cushing's disease: a primary disorder of the adrenal cortices? Ann NY Acad Sci 1948:50:657–678.

    Google Scholar 

  44. Bauer J. The so-called Cushing's syndrome, its history, terminology and differential diagnosis. Acta Med Scand 1950; 137:411–416.

    Google Scholar 

  45. Brown WH. A case of pluriglandular syndrome: “diabetes of bearded women”. Lancet 1928;2:1022–1023.

    Google Scholar 

  46. Achard C, Thiers T. Le virilisme pilaire (diabete des femmes a barbe). Bull Acad Natl Med (Paris) (3 series) 1921;86: 51–56.

    Google Scholar 

  47. Christy NP. Adrenocorticotrophic activity in the plasma of patients with Cushing's syndrome associated with pulmonary neoplasms. Lancet 1961;1:85–86.

    Google Scholar 

  48. Meador CK, Liddle GW, Island DP, et al. Cause of Cushing's syndrome in patients with tumors arising from “nonendocrine” tissue. J Clin Endocrinol Metab 1962;22:693–703.

    Google Scholar 

  49. Carey RM, Varma SK, Drake CR, Thorner MO, Kovacs K, Rivier J, Vale W. Ectopic secretion of corticotropin-releasing factor as a cause of Cushing's syndrome. N Engl J Med 1984;311:13–20.

    Google Scholar 

  50. Belsky JL, Cuello B, Svanson LW, Simmons DM, Jarrett RM, Brasa F. Cushing's syndrome due to ectopic production of corticotropin-releasing factor. J Clin Endocrinol Metab 1985;60:496–500.

    Google Scholar 

  51. Mosier HD, Flynn PJ, Will DW, Turner RD. Cushing's syndrome with multinodular adrenal glands. J Clin Endocrinol Metab 1960;20:632–640.

    Google Scholar 

  52. De Moor P, Roels H, Delaere K, Crabbé J. Unusual case of adrenocortical hyperplasia. J Clin Endocrinol Metab 1965; 25:612–620.

    Google Scholar 

  53. Meador CK, Bowdoin B, Owen WC Jr, Farmer TA Jr. Primary adrenocortical nodular dysplasia: a rare cause of Cushing's syndrome. J Clin Endocrinol Metab 1967;27:1255–1263.

    Google Scholar 

  54. Carney AJ, Gordon H, Carpenter PC, Shenoy BV, Go VLW. The complex of myxomas, spotty pigmentation, and endocrine overactivity. Medicine 1985;64:270–283.

    Google Scholar 

  55. Kirschner MA, Powell RD, Lipsett MB. Cushing's syndrome: nodular cortical hyperplasia of adrenal glands with clinical and pathologic features suggesting adrenocortical tumor. J Clin Endocrinol Metab 1964;24:947–955.

    Google Scholar 

  56. Lacroix A, Bolté E, Tremblay J, Dupré J, Poitras P, Foutnier H, et al. Gastric inhibitory polypeptide-dependent cortisol hypersecretion—a new cause of Cushing's syndrome. N Engl J Med 1992;327:974–980.

    Google Scholar 

  57. Reznik Y, Allali-Zerah V, Chayvialle JA, Leroyer R, Leymarie P, Travert G, et al. Food-dependent Cushing's syndrome mediated by aberrant adrenal sensitivy to gastric inhibitory polypeptide. N Engl J Med 1992;327:981–986.

    Google Scholar 

  58. Thornton JK. Abdominal nephrectomy for large sarcoma of the left suprarenal capsule: recovery. Trans Clin Soc Lond 1890;23:150–153.

    Google Scholar 

  59. Priestley JT, Sprague RG, Walters W, Salassa RM. Subtotal adrenalctomy for Cushing's syndrome. Ann Surg 1951;134: 464–472.

    Google Scholar 

  60. Nelson DH, Meakin JW, Thorn GW. ACTH producing pituitary tumours following adrenalectomy for Cushing's syndrome. Ann Intern Med 1960;52:560–569.

    Google Scholar 

  61. Horsley V. On the technique of operation on the central nervous system. Br Med J 1906;2:411–423.

    Google Scholar 

  62. Krause F. Hirnchurgie. I: Die deutsche Klinik am Eingange des zwanzigsten Jahrhunderts, vol. VIII. In: v. Leyden E, Klemperer F, eds Berlin, Wien: Urban & Schwarzenberg, 1905: p. 1004.

    Google Scholar 

  63. Schloffer, H. Erfolgreiche Operation eines Hypophysentumors auf nasalem Wege. Wien klin Wochensch 1907;20:621–624.

    Google Scholar 

  64. Hirsch O. Eine neue Methode der endonasalen Operation von Hypophysentumoren. Wien klin Wochensch 1909;21: 636–637.

    Google Scholar 

  65. Lisser H. Hypophysectomy in Cushing's disease. J Nerv Ment Dis 1944;99:727–733.

    Google Scholar 

  66. Arner B, Luft R, Olivecrona H, Sjögren B. Successful treatment of a case of Cushing's syndrome. J Clin Endocrinol Metab 1953;13:1101–1108.

    Google Scholar 

  67. Landolt A. Development of pituitary adenoma treatment—a critical essay. Pituitary 1999;2:103–112.

    Google Scholar 

  68. Osler W. On six cases of Addison's disease with the report of a case greatly benefited by the use of the suprarenal gland extract. Bull Johns Hopkins Hosp 1896;7:208–209.

    Google Scholar 

  69. Guiot G, Thibaut B. L'extirpation des adéenomes hypophysaires par voie transsphénoidale. Neurochirurgia 1959; 1:133–150.

    Google Scholar 

  70. Hardy J. Transsphenoidal microsurgery of the normal and pathological pituitary. Clin Neurosurg 1969;16:185–217.

    Google Scholar 

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  1. Division of Edocrinology, Holstebro Hospital, Holstebro, Denmark

    J. Lindholm

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Lindholm, J. Cushing's Syndrome: Historical Aspects. Pituitary 3, 97–104 (2000). https://doi.org/10.1023/A:1009905808033

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