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Mesothelial Cell Activation by Micro-Organisms

  • Published:
Sepsis

Abstract

In recent years research on peritonitis has focused on the mesothelial lining of the peritoneal cavity. Activation of this cell-layer by direct contact with micro-organisms is known to influence coagulation, fibrinolysis and inflammatory processes. This review summarizes the recent advances in activation mechanisms of mesothelial cells by micro-organisms. Between bacterial species striking differences in activation of mesothelium exist, resulting in a variey of effects. In future these insights may lead to new therapeutic options for bacterial peritonitis.

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Authors and Affiliations

  1. Department of Surgery, Netherlands

    Anneke M. Zeillemaker & Piet Leguit

  2. Department of Medical Microbiology, Diakonessen Hospital, Utrecht, The Netherlands

    Rob J.A. Diepersloot

Authors
  1. Anneke M. Zeillemaker
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  2. Rob J.A. Diepersloot
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  3. Piet Leguit
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Zeillemaker, A.M., Diepersloot, R.J. & Leguit, P. Mesothelial Cell Activation by Micro-Organisms. Sepsis 3, 285–291 (1999). https://doi.org/10.1023/A:1009897209650

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  • DOI: https://doi.org/10.1023/A:1009897209650

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