References
The Cardiac Arrhythmias Suppression Trial Investigators. Preliminary report: Effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N Engl J Med 1991;321:406–412.
Echt DS, Liebson PR, Mitchell B, Peters RW, Obias-Manno D, Barker AH, Arensberg D, Baker A, Friedman L, Greene HL, Huther ML, Richardson DW, and the CAST Investigators. Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med 1991;324:781–788.
The Cardiac Arrhythmia Suppression Trial II Investigators. Effect of the antiarrhythmic agent moricizine in survival after myocardial infarction. N Engl J Med 1992;327:227–233.
Akhtar M, Breithardt G, Camm AJ, Coumel P, Janse MJ, Lazzara R, Myerburg RJ, Schwartz PJ, Waldo AL, Wellens HJJ, Zipes DP. CAST and beyond: Implications of the Cardiac Arrhythmia Suppression Trial. Circulation 1990;81:1123–1127.
Myerburg RJ, Kessler KM, Castellanos A. Sudden cardiac death: Epidemiology, transient risk, and intervention assessment. Ann Intern Med 1993;119:1187–1197.
Myerburg RJ, Mitrani R, Interian A, and Castellanos A. Interpretation of outcomes of antiarrhythmic clinical trials: Design features and population impact. Circulation 1998;97: 1514–1521.
Lipid Research Clinics Program. The lipid research clinics primary prevention trial results. I and II. J Am Med Assoc 1984;251:351–374.
Frick MH, Elo O, Haapa KA, Heinonen OP, Heinsalma P, Helo P, Huttunen JK, Kaltaniem P, Koskinen P, Manninen V, Maenpaa H, Malkonen M, Manttari M, Norola S, Pasternack A, Pikkaralenan J, Romo M, Sjoblom T, Nikkila EA. Helsinki heart study: Primary prevention trial with gemfibrozil in middle-aged men with dyslipidemia. N Engl J Med 1987;317:1237–1245.
Sacks FM, Pfeffer MA, Moye LA, Rouleau JL, Rutherford JD, Cole G, Brown L, Warnica JW, Arnold JM, Wun CC, Davis BR, Braunwald E, for the Cholesterol and Recurrent Events Trial Investigators. The effect of pravastatin on coronary events after myocardial infarction in patientswith average cholesterol levels. N Engl J Med 1996;335:1001–1009.
Julian DG, Camm AJ, Fragin G, Janse MJ, Munoz A, Schwartz PJ, Simon P, for the Eüropean Myocardial Infarct Amiodarone Trial Investigators. Randomized trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT. Lancet 1997;349:667–674.
Cairns JA, Connolly SJ, Roberts R, Gent M, for the Canadian Amiodarone Myocardial Infarction Arrhythmia Trial Investigators. Randomized trial of outcome after myocardial infarction in patients with frequent or repetitive ventricular premature depolarizations: CAMIAT. Lancet 1997;349: 675–682.
Gottlieb SG. Dead is dead-Artificial definitions are no substitute. Lancet 1997;349:662–663.
Singh SN, Fletcher RD, Fisher SG, Singh BN, Lewis HD, Deedwania PC, Massie BM, Colling C, Lazzeri D. Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmia. Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure. N Engl J Med 1995;333:77–82.
Doval HC, Nul DR, Grancelli HO, Perrone SV, Bortman GR, Curiel R. Randomized trial of low-dose amiodarone in severe congestive heart failure. Lancet 1994;344:493–498.
The CASCADE Investigators. Randomized antiarrhythmic drug therapy in survivors of cardiac arrest (the CASCADE study). Am J Cardiol 1993;72:280–287.
Waldo AL, Camm AJ, deRuyter H, Friedman PL, MacNeil DJ, Pauls JF, Pitt B, Pratt CM, Schwartz PJ, Veltri EP, for the SWORD Investigators. Effect of d-sotolol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. Lancet 1996;348:7–12.
Siebels J, Cappato R, Rüppel R, Schneider MAE, Kuch KH, and the CASH Investigators. Preliminary results of the Cardiac Arrest Study Hamburg (CASH). Am J Cardiol 1993;72:109F-113F.
The Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators. A comparison of antiarrhythmic-drug therapy with implantable defibrillators in patients resuscitated from near-fatal ventricular arrhythmias. N Engl J Med 1997;337:1576–1583
Moss AJ, Hall WJ, Cannom DS, Daubert JP, Higgens SL, Klein H, Levine JH, Saksena S, Waldo AL, Wilber D, Brown MW, Heo M, for the Multicenter Automatic Defibrillator Implantation Trial Investigators: Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. N Engl J Med 1996; 335:1933–1940.
Hebert PR, Gaziano JM, Chan KS, Hennekens CH. Cholesterol lowering with statin drugs, risk of stroke, and total mortality: An overview of randomized trials. JAMA 1997; 278:313–321.
Myerburg RJ, Kessler KM, Castellanos A. Sudden cardiac death: Structure, function, and time-dependence of risk. Circulation 1992;85(1 Suppl):I-2-I-10.
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[Dr. Myerburg is funded in part by the American Heart Association Chair in Cardiovascular Research at the University of Miami
[Dr. Myerburg is funded in part by the American Heart Association Chair in Cardiovascular Research at the University of Miami
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Myerburg, R.J., Mitrani, R., Interian, A. et al. The Interpretation and Clinical Application of Data from Trials on Sudden Cardiac Death. J Interv Card Electrophysiol 4 (Suppl 1), 95–102 (2000). https://doi.org/10.1023/A:1009886700374
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DOI: https://doi.org/10.1023/A:1009886700374