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Oxidative Stress, Vascular Dysfunction and Heart Failure

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References

  1. Lohse MJ, Engelhardt S, Danner S, Bohm M. Mechanisms of beta-adrenergic receptor desensitization: From molecular biology to heart failure. Basic Research in Cardiology 1996;91(Suppl 2):29–34.

    Google Scholar 

  2. Ping P, Anzai T, Gao M, Hammond HK. Adenylyl cyclase and G protein receptor kinase expression during development of heart failure. Am J Physiol 1997;273:H707–H717.

    Google Scholar 

  3. Remme WJ. Prevention of worsening heart failure: Future focus. Eur Heart J 1998;19:B47–B53.

    Google Scholar 

  4. Sakai S, Miyauchi T, Kobayashi M, Yamaguchi I, Goto K, Sugishita Y. Inhibition of myocardial endothelin pathway improves long-term survival in heart failure. Nature 1996;384:353–355.

    Google Scholar 

  5. Wei CM, Lehman A, Rodeheffer RJ, et al. Endothelin in human congestive heart failure. Circulation 1994;89: 1580–1586.

    Google Scholar 

  6. Stewart D. Update on endothelin. Can J Cardiol 1998;14(Suppl D):11D–13D.

    Google Scholar 

  7. Drexler H, Hayoz D, Münzel T, Just HJ, Zelis R, Brunner HR. Endothelial function in congestive heart failure. Am Heart J 1993;126:761–764.

    Google Scholar 

  8. Drexler H. Changes in the peripheral circulation in heart failure. Curr Opin Cardiol 1995;10: 268–273.

    Google Scholar 

  9. Wang J, Seyedi N, Xu X-B, Wolin MS, Hintze TH. Defective endothelium-mediated control of coronary circulation in conscious dogs after heart failure. Am J Physiol Heat Circ 1994;266:H670–H680.

    Google Scholar 

  10. Stewart JM, Wang J, Hintze TH. Role of EDRF in the regulation of shear rate in large coronary arteries in conscious dogs. J Mol Cell Cardiol 1994;26:1625–1633.

    Google Scholar 

  11. Hayoz D, Drexler H, Münzel T, et al. Flow mediated arterial dilation is abnormal in congestive heart failure. Circulation 1993;87:VII-92–VII-96.

    Google Scholar 

  12. Drexler H, Hayoz D, Münzel T, et al. Endothelial function in chronic congestive heart failure. Am J Cardiol 1992;69:1596–1601.

    Google Scholar 

  13. Drexler H. Skeletal muscle failure in heart failure. Circulation 1992;85:1621–1623.

    Google Scholar 

  14. Mancini DM, Wilson JR, Bolinger L, et al. In vivo magnetic resonance spectroscopy measurement of deoxymyoglobin during exercise in patients with heart failure: Demonstration of abnormal muscle metabolism despite adequate oxygenagion. Circulation 1994;90:500–508.

    Google Scholar 

  15. Hornig B, Maier V, Drexler H. Physical training improves endothelial function in patients with chronic heart failure. Circulation 1996;93:210–214.

    Google Scholar 

  16. Devaux B, Scholz D, Hirche A, Klovekorn WP, Schaper J. Upregulation of cell adhesion molecules and the presence of low grade inflammation in human chronic heart failure. Eur Heart J 1997;18:470–479.

    Google Scholar 

  17. Aukrust P, Ueland T, Muller F, et al. Elevated circulating levels of C-C chemokines in patients with congestive heart failure. Circulation 1998;97:1136–1143.

    Google Scholar 

  18. Yoshizumi M, Perella MA, Burnett JC, Lee ME. Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ Res 1993; 73:205–209.

    Google Scholar 

  19. Aoki N, Siegfried M, Lefer AM. Anti-EDRF effect of tumor necrosis factor in isolated, perfused cat carotid arteries. am J Physiol 1989;256:H1509–H1512.

    Google Scholar 

  20. Levine B, Kalman J, Mayer L, Fillit HM, Packer M. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 1990;323:236–241.

    Google Scholar 

  21. Katz SD, Rao R, Berman JW, et al. Pathophysiological correlates of increased serum tumor necrosis factor in patients with congestive heart failure: Relation to nitric oxide-dependent vasodilation in the forearm circulation. Circulation 1994;90:12–16.

    Google Scholar 

  22. Testa M, Yeh M, Lee P, et al. Circulating levels of cytokines and their endogenous modulators in patients with mild to severe congestive heart failure due to coronary artery disease or hypertension. J Am Coll Cardiol 1996;28:964–971.

    Google Scholar 

  23. Torre-Amione G, Kapadia S, Lee J, et al. Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart. Circulation 1996;93:704–711.

    Google Scholar 

  24. Mann DL, Young JB. Basic mechanisms in congestive heart failure. Recognizing the role of proin_ammatory cytokines. Chest 1994;105:897–904.

    Google Scholar 

  25. Hill MF, Singal PK. Antioxidant and oxidative stress changes during heart failure subsequent to myocardial infarction in rats. Am J Pathol 1996;148:291–300.

    Google Scholar 

  26. Ferrari R, Bachetti T, Confortini R. Tumor necrosis factor soluble receptors in patients with various degrees of congestive heart failure. Circulation 1995;92:1479–1486.

    Google Scholar 

  27. Packer M. Is tumor necrosis factor an important neurohormonal mechanism in chronic heart failure? Circulation 1995;92:1379–1382.

    Google Scholar 

  28. Keith M, Geranmayegan A, Sole MJ, et al. Increased oxidative stress in patients with congestive heart failure. J Am Coll Cardiol 1998;31:1352–1356.

    Google Scholar 

  29. Ferrari R, Agnoletti L, Comini L, et al. Oxidative stress during myocardial ischaemia and heart failure. Eur Heart J 1998;19(Suppl B):B2–B11.

    Google Scholar 

  30. Winlaw DS, Smythe GA, Keogh AM, Schyvens CG, Spratt PM, Macdonald PS. Increased nitric oxide production in heart failure. Lancet 1994;344:373–374.

    Google Scholar 

  31. Habib FM, Springall DR, Davies GJ, Oakley CM, Yacoub MH, Polak JM. Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy. Lancet 1996;347:1151–1155.

    Google Scholar 

  32. Haywood GA, Tsao PS, von dLE, et al. Expression of inducible nitric oxide synthase in human heart failure. Circulation 1996;93:1087–1094.

    Google Scholar 

  33. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitriteimplications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990;87:1620–1624.

    Google Scholar 

  34. Buttery LD, Springall DR, Chester AH, et al. Inducible nitric oxide synthase is present within human atherosclerotic lesions and promotes the formation and activity of peroxynitrite. Lab Invest 1996;75:77–85.

    Google Scholar 

  35. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 1994;74:1141–1148.

    Google Scholar 

  36. Fukui T, Ishizaka N, Rajagopalan S, et al. p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. Circ Res 1997;80:45–51.

    Google Scholar 

  37. De KGW, Alexander RW, Ushio-Fukai M, Ishizaka N, Griendling KK. Tumour necrosis factor alpha activates a p22phox-based NADH oxidase in vascular smooth muscle. Biochem J 1998;329:653–657.

    Google Scholar 

  38. Ushio-Fukai M, Alexander RW, Akers M, Griendling KK. p38 Mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II. Role in vascular smooth muscle cell hypertrophy. J Biol Chemi 1998;273:15022–15029.

    Google Scholar 

  39. Darley-Usmar VM, Wiseman H, Halliwell B. Nitric oxide and oxygen radicals: A question of balance. FEBS Lett 1995;369:131–135.

    Google Scholar 

  40. Dhalla AK, Hill MF, Singal PK. Role of oxidative stress in transition of hypertrophy to heart failure. J Am Coll Cardiol 1996;28:506–514.

    Google Scholar 

  41. Hill MF, Singal PK. Right and left myocardial antioxidant responses during heart failure subsequent to myocardial infarction. Circulation 1997;96:2414–2420.

    Google Scholar 

  42. Dhalla AK, Singal PK. Antioxidant changes in hypertrophied and failing guinea pig hearts. Am J Physiol 1994;266:H1280–H1285.

    Google Scholar 

  43. Singh N, Dhalla AK, Seneviratne C, Singal PK. Oxidative stress and heart failure. Mol Cell Biochem 1995;147:77–81.

    Google Scholar 

  44. Diaz-Velez CR, Garcia-Castineiras S, Mendoza-Ramos E, Hernandez-Lopez E. Increased malondialdehyde in peripheral blood of patients with congestive heart failure. Am Heart J 1996;131:146–152.

    Google Scholar 

  45. Belch JJF, Bridges AB, Scott N, Chopra M. Oxygen free radicals and congestive heart failure. Br Heart J 1991;6545–248.

  46. Mallat Z, Philip I, Lebret M, Chatel D, Maclouf J, Tedgui A. Elevated levels of 8-isoprostaglandin F2alpha in pericardial fluid of patients with heart failure: A potential role for in vivo oxidants stress in ventricular dilatation and progression to heart failure. Circulation 1998;97:1536–1539.

    Google Scholar 

  47. Hornig B, Arakawa N, Kohler C, Drexler H. Vitamin C improves endothelial function of conduit arteries in patients with chronic heart failure. Circulation 1998;97:363–368.

    Google Scholar 

  48. Dikalov S, Fink B, Skatchkov M, Bassenge E. Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of suproxide radicals: Effect of Vitamin C. Free Radical. Biol. Med. 1999;27(1/2): 169–175.

    Google Scholar 

  49. Münzel T, Sayegh H, Freeman BA, Tarpey MM, Harrison DG. Evidence for enhanced vascular superoxide anion production in nitrate tolerance. J Clin Invest 1995;95:187–194.

    Google Scholar 

  50. Dikalov S, Fink B, Skatchkov M, Bassenge E. Formation of reactive oxygen species by PETN and GTN in vitro and development of nitrate tolerance. J Pharmacol Exp Ther 1998;286:938–944.

    Google Scholar 

  51. Johnson C, Stubley-Beedham C, Stell JGP. Hydralazine: A potent inhibitor of aldehyde oxidase activity in vitro and in vivo. Biochem Pharmacol 1985;34:4251–4256.

    Google Scholar 

  52. Atwal KS. Pharmacology and structure-activity relationships for KATP modulators: Tissue-selectiveKATP openers. J Cardiovasc Pharmacol 1994;24(Suppl 4):S12–S17.

    Google Scholar 

  53. Dikalov S, Skatchkov M, Fink B, Sommer O, Bassenge E. Formation of reactive oxygen species in various vascular cells during glyceryltrinate metabolism. J Cardiovasc Pharmacol Ther 1998;3:51–62.

    Google Scholar 

  54. Dikalov S, Kirilyuk I, Grigor'ev I. Spin trapping of O-, C-, and S-centered radicals and peroxynitrite by 2H-imidazole-1-oxides. Biochem Biophys Res Commun 1996;218:616–622.

    Google Scholar 

  55. Fink B, Bassenge E. Unexpected, tolerance-devoid vasomotor and platelet actions of pentaerytrityl tetranitrate. J Cardiovasc Pharmacol 1997;30:831–836.

    Google Scholar 

  56. Kojda G, Stein D, Kottenberg E, Schnaith EM, Noack E. In vivo effects of pentaerythrityl-tetranitrate and isosorbide-5-mononitrate on the development of atherosclerosis and endothelial dysfunction in cholesterol-fed rabbits. J Cardiovasc Pharmacol 1995;25:763–773.

    Google Scholar 

  57. Szabo C, Zingarelli B, Salzman AL. Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Cir Res 1996;78:1051–1063.

    Google Scholar 

  58. Nossuli TO, Hayward R, Jensen D, Scalia R, Lefer AM. Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury. Am J Physiol 1998;275:H509–H519.

    Google Scholar 

  59. Bachmaier K, Neu N, Pummerer C, et al. iNOS expression and nitrotyrosine formation in the myocardium in response to in_ammation is controlled by the interferon regulatory transcription factor 1. Circulation 1997;96:585–591.

    Google Scholar 

  60. Liu P, Hock CE, Nagele R, Wong PY. Formation of nitric oxide, superoxide, and peroxynitrite in myocardial ischemiareperfusion injury in rats. Am J Physiol 1997;272:H2327–H2336.

    Google Scholar 

  61. Skatchkov M, Larina L, Larin A, Fink N, Bassenge E. Urinary nitrotyrosine content as a marker of peroxynitrite-induced tolerance to organic nitrates. J Cardiovasc Pharmacol Ther 1997;2:85–96.

    Google Scholar 

  62. Bassenge E, Fink B. Tolerance to nitrates and simultaneous upregulation of platelet activity prevented by enhancing antioxidant state. Naunyn-Schmiedeberg's Arch Pharmacol 1996;353:363–367.

    Google Scholar 

  63. Münzel T, Kurz S, Rajagopalan S, et al. Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug. J Clin Invest 1996;98:1465–1470.

    Google Scholar 

  64. Schwemmer M, Bassenge E. Substantially altered gene expression in platelets during non-intermittent glyceryl trinitrate. 2 Int Congress, Coronary Artery Disease 1998; 15(Abstract)

  65. Braughler JM. Soluble guanylate cyclase activation by nitric oxide and its reversal. Involvement of sulfhydryl group oxidation and reduction. Biochem Pharmacol 1983;32:811–818.

    Google Scholar 

  66. Shen W, Lundborg M, Wang J, et al. Role of EDRF in the regulation of regional blood flow and vascular resistance at rest and during exercise in conscious dogs. J Appl Physiol 1994;77:165–172.

    Google Scholar 

  67. Singh RB, Niaz MA, Rastogi SS, Rastogi S. Usefulness of antioxidant vitamins in suspected acute myocardial infarction (the Indian experiment of infarct survival-3). Am J Cardiol 1996;77:232–236.

    Google Scholar 

  68. Ghatak A, Brar MJ, Agarwal A, et al. Oxy free radical system in heart failure and therapeutic role of oral vitamin E. Int J Cardiol 1996;57:119–127.

    Google Scholar 

  69. Ito K, Akita H, Kanazawa K, et al. Comparison of effects of ascorbic acid on endothelium-dependent vasodilation in patients with chronic congestive heart failure secondary to idiopathic dilated cardiomyopathy versus patients with effort angina pectoris secondary to coronary artery disease. Am J Cardiol 1998;82:762–767.

    Google Scholar 

  70. Heitzer T, Just HJ, Münzel T. Antioxidant vitamin C improves endothelial dysfunction in chronic smokers. Circulation 1996;94:6–9.

    Google Scholar 

  71. Feuerstein G, Yue TL, Ma X, Ruffolo RR. Novel mechanisms in the treatment of heart failure: Inhibition of oxygen radicals and apoptosis by carvedilol. [Review] [35 refs]. Prog Cardiovasc Dis 1998;48:17–24.

    Google Scholar 

  72. Iliskovic N, Singal PK. Lipid lowering: An important factor in preventing adriamycin-induced heart failure. Am J Pathol 1997;150:727–734.

    Google Scholar 

  73. Lechat P, Packer M, Chalon S, Cucherat M, Arab T, Boissel JP. Clinical effects of beta-adrenergic blockade in chronic heart failure: A meta-analysis of double-blind, placebo-controlled, randomized trials. Circulation 1998;98:1184–1191.

    Google Scholar 

  74. Khaper N, Singal PK. Effects of afterload-reducing drugs on pathogenesis of antioxidant changes and congestive heart failure in rats. J Am Coll Cardiol 1997;29:856–861.

    Google Scholar 

  75. Jafri SM, Ozawa T, Mammen E, Levine TB, Johnson C, Goldstein S. Platelet function, thrombin and fibrinolytic activity in patients with heart failure. Eur Heart J 1993;14:205–212.

    Google Scholar 

  76. Trip MD, Cats VM, van CFJ, Vreeken J. Platelet hyperreactivity and prognosis in survivors of myocardial infarction. N Eng J Med 1990;322:1549–1554.

    Google Scholar 

  77. Meade TW, Mellows S, Brozovic M, et al. Haemostatic function and ischaemic heart disease: Principal results of the Northwick Park Heart Study. Lancet 1986;2:533–537.

    Google Scholar 

  78. Dunkman WB, Johnson GR, Carson PE, Bhat G, Farrell L, Cohn JN. Incidence of thromboembolic events in congestive heart failure. The V-HeFT VA Cooperative Studies Group. Circulation 1993;87:VI94–101.

    Google Scholar 

  79. Bassenge E, Fink N, Skatchkov M, Fink B. Dietary supplement with vitamin C prevents nitrate tolerance. J Clin Invest 1998;102:67–71.

    Google Scholar 

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  1. Institute of Applied Physiology, Albert-Ludwigs University, Freiburg, Germany

    Eberhard Bassenge, Bruno Fink & Michael Schwemmer

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Bassenge, E., Fink, B. & Schwemmer, M. Oxidative Stress, Vascular Dysfunction and Heart Failure. Heart Fail Rev 4, 1–13 (1999). https://doi.org/10.1023/A:1009820324010

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