Skip to main content
SpringerLink
Log in

Measuring the Biological Efficacy of Mediator-Directed Therapy

  • Published:
Sepsis

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Bibliography

  • American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992;20:864–874.

    Google Scholar 

  • Bone RC, Fisher CJ, Clemmer TP. A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 1987;317:653–659.

    Google Scholar 

  • Deitch EA, Winterton J, Bey R. The gut as the portal of entry for bacteremia. Ann Surg 1987;205: 681–692.

    Google Scholar 

  • Dinarello CA, Cannon JG, Wolff SM. Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin-1. J Exp Med 1986; 163:1433–1450.

    Google Scholar 

  • Fisher CJ Jr, Dhainaut JF, Opal SM, et al. Recombinant human interleukin-1 receptor antagonist in the treatment of patients with sepsis syndrome: Results from a randomized, double-blind, placebo-controlled trail. JAMA 1994;271:1836–1843.

    Google Scholar 

  • Fry D, Pearlstein L, Fulton R. Multiple system organ failure. The role of uncontrolled infection. Arch Surg 1980;115:136–140.

    Google Scholar 

  • Greenman RL, Schein RMH, Martin MA. A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. JAMA 1881;266:1097–1102.

    Google Scholar 

  • Hack CE, DeGroot ER, Felt-Bersma RJF, Nuijem JH, Stack van Schijundel RS, Erenberg-Belmer AJ: Increased plasma levels of interleukin-6 in sepsis. Blood 1989;74:1704–1710.

    Google Scholar 

  • Knaus WA, Draper EA, Wagner DP, Zimmerman JE. Prognosis in acute organ-system failure. Ann Surg 1985;202:685–693.

    Google Scholar 

  • Matuschak GM, Rinaldo JE. Organ interactions in the adult respiratory distress syndrome during sepsis. Role of the liver in host defense. Chest 1988;94:400–406.

    Google Scholar 

  • Pinsky MR, Matuschak GM. Multiple systems organ failure: a unifying hypothesis. J Crit Care 1990;5:108–114.

    Google Scholar 

  • Pinsky MR, Vincent JL, Deviere J, Alegre M, Kahn R, Dupont E. Serum cytokine levels in human septic shock: Relation to multiple systems organ failure and mortality. Chest 1993;103: 565–575.

    Google Scholar 

  • Rosenbloom A, Pinsky MR, Bryant JL, Shin A, Tran T, Whiteside T. Leukocyte activation in the peripheral blood of patients with cirrhosis of the liver and SIRS: Correlation with serum interleukin-6 levels and organ dysfunction. JAMA 1995;274:58–65.

    Google Scholar 

  • Wenzel RP, Pinsky MR, Ulevitch RJ, Young L. Current Understanding of Sepsis. Clin Infectious Diseases 1996;22:407–413.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Critical Care Medicine, University of Pittsburgh Medical Center, USA

    Michael R. Pinsky

Authors
  1. Michael R. Pinsky
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pinsky, M.R. Measuring the Biological Efficacy of Mediator-Directed Therapy. Sepsis 1, 65–67 (1997). https://doi.org/10.1023/A:1009723604209

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1009723604209

Keywords

Search

Navigation