Abstract
A simple and general approach to the synthesis of chemical libraries based on a universal anhydride template allows the preparation of large number of compounds. Various cyclic/acyclic amines, primary/secondary amines, differentially protected bifunctional amines were used as nucleophiles to react with anhydrides. The free carboxylic acid generated was then coupled with solid-bound amines. The facile and rapid generation of compounds through this multi-component assembly can be accomplished in a combinatorial parallel synthesis.
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Perumattam, J., Chakravarty, S., McEnroe, G.A. et al. Solid phase synthesis of combinatorial libraries using anhydrides as templates. Mol Divers 3, 121–128 (1997). https://doi.org/10.1023/A:1009662605993
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DOI: https://doi.org/10.1023/A:1009662605993