Abstract
A Lead Discovery Library ofpiperazine-2-carboxamide derivatives was produced forgeneral screening. This paper discloses two novelsolid phase synthetic routes used to produce 15 000single compounds via the Irori directed sortingtechnique. Computational methods such as reagentclustering and library profiling were used to maximizereagent diversity and optimize pharmacokineticparameters. The results of a four center pharmacophoreanalysis revealed the added diversity gained by usingtwo independent synthetic routes.
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Herpin, T.F., Morton, G.C., Dunn, A.K. et al. Synthesis and diversity analysis of lead discovery piperazine-2-carboxamide libraries. Mol Divers 4, 221–232 (1998). https://doi.org/10.1023/A:1009637817478
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DOI: https://doi.org/10.1023/A:1009637817478