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Comparative Study of DNA-Specific Dyes of the Indole and Benzimidazole Series

Russian Journal of Bioorganic Chemistry volume 27, pages 57–65 (2001)Cite this article

Abstract

Various models of complex formation of low-molecular ligands with DNA are considered. Using the Scatchard model, parameters of binding of fluorescent monophenylindole, monophenylbenzimidazole, and bisbenzimidazole dyes with calf thymus DNA were evaluated. By means of graphic (nonparametric) and correlation analysis, various spectral and complexation properties of these dyes in the presence of DNA are compared.

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Authors and Affiliations

  1. Central Research Institute of Roentgenology and Radiology, Russian Ministry of Public Health, Leningradskaya ul. 70/4, Pesochny-2, St. Petersburg, 189646, Russia

    V. S. Sibirtsev & S. D. Ivanov

  2. St. Petersburg State Technological Institute, St. Petersburg, Russia

    A. V. Garabadzhiu

Authors
  1. V. S. Sibirtsev
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  2. A. V. Garabadzhiu
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  3. S. D. Ivanov
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Sibirtsev, V.S., Garabadzhiu, A.V. & Ivanov, S.D. Comparative Study of DNA-Specific Dyes of the Indole and Benzimidazole Series. Russian Journal of Bioorganic Chemistry 27, 57–65 (2001). https://doi.org/10.1023/A:1009535320077

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  • DOI: https://doi.org/10.1023/A:1009535320077

  • DNA
  • complex formation
  • benzimidazoles
  • phenylindoles