Journal of Assisted Reproduction and Genetics

, Volume 17, Issue 3, pp 174–177 | Cite as

Gynecology: Low-Dose Aspirin for Infertile Women with Thin Endometrium Receiving Intraeuterine Insemination: A Prospective, Randomized Study

  • Yao-Yuan Hsieh
  • Horng-Der Tsai
  • Chi-Chen Chang
  • Hui-Yu Lo
  • Ching-Lun Chen
Article

Abstract

Purpose: The objective was to evaluate the effect of aspirinon infertile women with thin endometrium.

Methods: Patients who had thin endometrium (≤ 8 mm)and intrauterine insemination were divided into the aspirinand nonaspirin groups. Endometrial pattern (trilaminar andnontrilaminar) and thickness, the pulsatility index (PI) andresistance index (RI) of the uterine artery, spiral artery, andovarian dominant follicles, and pregnancy rates of bothgroups were measured.

Results: A total of 114 and 122 women were included inthe aspirin and nonaspirin groups, respectively. There weresignificantly higher percentages of trilaminar endometrium(46.5% vs. 26.2%) and pregnancy rate (18.4% vs. 9.0%)after aspirin therapy. There was nonsignificant differencein the endometrial thickness, and PI/RI values of the uterineartery, spiral artery, and ovarian dominant follicle betweenboth groups.

Conclusions: Higher pregnancy rate and better endometrialpattern were achieved in patients with thin endometriumafter aspirin administration. Aspirin therapy could notsignificantly increase the endometrial thickness and theresistance of uterine and ovarian flow.

Aspirin intrauterine insemination spiral artery thin endometrium uterine artery 

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Copyright information

© Plenum Publishing Corporation 2000

Authors and Affiliations

  • Yao-Yuan Hsieh
    • 1
  • Horng-Der Tsai
    • 1
  • Chi-Chen Chang
    • 1
  • Hui-Yu Lo
    • 1
  • Ching-Lun Chen
    • 1
  1. 1.Department of Obstetrics and GynecologyChina Medical College HospitalTaichungTaiwan

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