Abstract
Purpose: Intracytoplasmic sperm injection (ICSI) of some sibling oocytes may have a beneficial effect in couples going through in vitro fertilization for causes of infertility not related to the male factor. Our purpose was to critically appraise the randomized controlled studies done in this area and arrive at some recommendations.
Methods: The four controlled trials done so far have utilized similar methodology, i.e., they randomly allotted sibling oocytes to ICSI versus standard insemination in patients going through in vitro fertiliztion and embryo transfer.
Results: In the first trial reported in 1995 there was no difference in fertilization rate, whereas the later trials reported in 1997, 1999, and 2000 showed improvement with ICSI that reached statistically significant level in the last two studies.
Conclusions: Total fertilization failure of an in vitro fertilization cycle can be prevented and fertilization can be improved if half of sibling oocytes are subjected to ICSI.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
Van Steirteghem AC, Nagy Z, Joris H, Liu J, Staessen C, Smitz J, Wisanto A, Devroey P: High fertilization and implantation rates after intracytoplasmic sperm injection. Hum Reprod 1993;8:1061-1066
Aboulghar MA, Mansour RT, Serour GI, Sattar MA, Amin YM: Intracytoplasmic sperm injection and conventional in vitro fertilization for sibling oocytes in cases of unexplained infertility and borderline semen. J Assist Reprod Genet 1996;13:38-42
Ruiz A, Remohi J, Minguez Y, Guanes PP, Simon C, Pellicer A: The role of in vitro fertilization and intracytoplasmic sperm injection in couples with unexplained infertility after failed intrauterine insemination. Fertil Steril 1997;68:171-173
Jun JH, Lim CK, Kim JW, Son IP, Koong MK, Song IO, Song JH, Yoo KJ, Kang IS: Comparison of fertilization and embryonic development between conventional insemination and ICSI treatment in the sibling oocytes of non-male factor infertility [abstract no. O-014]. Am Soc Reproduct Med 1999; 72(Suppl.1):S6
Khamsi F, Yavas Y, Roberge S, Wong J, Lacanna IC, The BL, Endman M: Intracytoplasmic sperm injection increased fertilization and good-quality embryo formation in patients with non-male indications for in vitro fertilization. A prospective randomized study. 2000; accepted, Fertil Steril
Boundelle M, Legein J, Buysse A, Van Assche E, Wisanto A, Devroey P: Prospective follow-up study of 432 children born after intracytoplasmic sperm injection. Hum Reprod 1996;11: 101-107
Schattman G, Rosenwaks Z, Berkely A: Congenital malformations in children born utilizing the assisted reproductive technologies. In Serono International Symposium on Genetics of Gametes and Embryos. New York, 1995, p 36
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Khamsi, F., Yavas, Y., Roberge, S. et al. The Status of Controlled Prospective Clinical Trials for Efficacy of Intracytoplasmic Sperm Injection in In Vitro Fertilization for Non-Male Factor Infertility. J Assist Reprod Genet 17, 504–507 (2000). https://doi.org/10.1023/A:1009441808115
Issue Date:
DOI: https://doi.org/10.1023/A:1009441808115