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Ca 2+ /Calmodulin-dependent protein kinase IV and calcium signaling

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Abstract

Ca 2+ /calmodulin dependent protein kinase IV (CaMKIV) is a multifunctional, serine-threonine protein kinase that is activated in the presence of increased intracellular calcium ( Ca 2+ ).CaMKIV is a potent medi-ator of Ca 2+ induced gene expression, primarily through its ability to phosphorylate and activate transcrip-tion factors such as CREB. CaMKIV-dependent activation of CREB is a key event in the expression of genes involved in the processes of T-cell activation and neuronal long term potentiation. The focus of this review is to describe the biochemical regulation of CaMKIV and examine how CaMKIV activates tran-scription in response to calcium in both cell and animal models.© Kluwer Academic Publishers

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  1. Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813, Durham, NC, 27710, U.S.A

    Kristin A Anderson & Christopher D Kane

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  1. Kristin A Anderson
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Anderson, K.A., Kane, C.D. Ca 2+ /Calmodulin-dependent protein kinase IV and calcium signaling. Biometals 11, 331–343 (1998). https://doi.org/10.1023/A:1009276932076

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