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Inhibition of Condensation in Human Chromosomes Induced by the Thymidine Analogue 5-iododeoxyuridine

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References

  • Bick MD, Devine EA (1977) Interaction of chromosomal proteins with BrdU substituted DNA as determined by chromatin-DNA competition. Nucleic Acids Res 4: 3687–3700.

    Google Scholar 

  • Bostock CJ, Sumner AT (1978) The Eukaryotic Chromosome. Amsterdam: Elsevier.

    Google Scholar 

  • Caspersson T, Zech L, Johansson C, Modest EJ (1970) Identification of human chromosomes by DNA-binding fluorescent agents. Chromosoma 30: 215–227.

    Google Scholar 

  • Comings DE, Riggs AD (1971) Molecular mechanisms of chromosome pairing, folding and function. Nature 233: 48–50.

    Google Scholar 

  • Dutrillaux B, Lejeune J (1971) A new technic of analysis of the human karyotype. C R Acad Sci Hebd Sciences Acad Sci D 272: 2638–2640.

    Google Scholar 

  • Fisher EF, Caruthers MH (1979) Studies on gene control regions XII. The functional significance of a lac operator constitutive mutation. Nucleic Acids Res 7: 401–416.

    Google Scholar 

  • Gosden JR, Mitchell AR, Buckland RA, Clayton RP, Evans HJ (1975) The location of four human satellite DNAs on human chromosomes. Exp Cell Res 92: 148–158.

    Google Scholar 

  • Goz B, Walker KP (1978) An immunological and biochemical analysis of alkaline phosphatase in HeLa cells exposed to 5-iodo-2′-deoxyuridine. Biochem Pharmacol 27: 431–436.

    Google Scholar 

  • Haaf T, Feichtinger W, Guttenbach M, Sanchez L, Muller CR, Schmid M (1989) Berenil-induced undercondensation in human heterochromatin. Cytogenet Cell Genet 50: 27–33.

    Google Scholar 

  • Jones KW (1973) Satellite DNA. J Med Genet 10: 273–281.

    Google Scholar 

  • Jones PA, Taylor SM (1980) Cellular differentiation, cytidine analogs and DNA methylation. Cell 20: 85–93.

    Google Scholar 

  • Jones PA, Taylor SM (1981) Hemimethylated duplex DNAs prepared from 5-azacytidine-treated cells. Nucleic Acids Res 9: 2933–2947.

    Google Scholar 

  • Krumdieck CL, Howard Peebles PN (1983) On the nature of folic-acid-sensitive fragile sites in human chromosomes: an hypothesis. Am J Med Genet 16: 23–28.

    Google Scholar 

  • Marcus M, Goitein R, Gropp A (1979) Condensation of all human chromosomes in phase G2 and early mitosis can be drastically inhibited by 33258-Hoechst treatment. Hum Genet 51: 99–105.

    Google Scholar 

  • Miklos GL, John B (1979) Heterochromatin and satellite DNA in man: properties and prospects. Am J Hum Genet 31: 264–280.

    Google Scholar 

  • Prantera G, Pimpinelli S, Rocchi A (1979) Effects of distamycin A on human leukocytes in vitro. Cytogenet Cell Genet 23: 103–107.

    Google Scholar 

  • Razin A, Cedar H (1977) Distribution of 5-methylcytosine in chromatin. Proc Natl Acad Sci USA 74: 2725–2728.

    Google Scholar 

  • Razin A, Riggs AD (1980) DNA methylation and gene function. Science 210: 604–610.

    Google Scholar 

  • Schmid M, Poppen A, Engel W (1981) The effects of distamycin A on gorilla-, chimpanzee-and orangutan lymphocyte cultures. Cytogenet Cell Genet 30: 211–221.

    Google Scholar 

  • Schmid M, Hungerford DA, Poppen A, Engel W (1984a) The use of distamycin A in human lymphocyte cultures. Hum Genet 65: 377–384.

    Google Scholar 

  • Schmid M, Haaf T, Grunert D (1984b) 5-Azacytidine-induced undercondensations in human chromosomes. Hum Genet 67: 257–263.

    Google Scholar 

  • Schmid M, Ott G, Haaf T, Scheres JM (1985) Evolutionary conservation of fragile sites induced by 5-azacytidine and 5-azadeoxycytidine in man, gorilla, and chimpanzee. Hum Genet 71: 342–350.

    Google Scholar 

  • Schmid M, Haaf T, Ott G, Scheres JM, Wensing JA (1986) Heterochromatin in the chromosomes of the gorilla: characterization with distamycin A/DAPI, D287/170, chromomycin A3, quinacrine, and 5-azacytidine. Cytogenet Cell Genet 41: 71–82.

    Google Scholar 

  • Schweizer D (1980) Simultaneous fluorescent staining of R bands and specific heterochromatic regions (DA-DAPI bands) in human chromosomes. Cytogenet Cell Genet 27: 190–193.

    Google Scholar 

  • Sumner AT (1972) A simple technique for demonstrating centromeric heterochromatin. Exp Cell Res 75: 304–306.

    Google Scholar 

  • Sutherland GR, Jacky PB, Baker E, Manuel A (1983) Heritable fragile site on human chromosomes. X. New folate-sensitive fragile sites: 6p23, 9p21, 9q32, and 11q23. Am J Hum Genet 35: 432–437.

    Google Scholar 

  • Sutherland GR, Parslow MI, Baker E (1985) New classes of common fragile sites induced by 5-azacytidine and bromo-deoxyuridine. Hum Genet 69: 233–237.

    Google Scholar 

  • Tommerup N (1984) Idoxuridine induction of micronuclei containing the long or short arms of human chromosome 9. Cytogenet Cell Genet 38: 92–98.

    Google Scholar 

  • Trifonov EN, Sussman JL (1980) The pitch of chromatin DNA is reflected in its nucleotide sequence. Proc Natl Acad Sci USA 77: 3816–3820.

    Google Scholar 

  • Zakharov AF, Baranovskaya LI, Ibraimov AI, Benjusch VA, Demintseva VS, Oblapenko NG (1974) Differential spiralization along mammalian mitotic chromosomes. II. 5-bromodeoxyuridine and 5-bromodeoxycytidine-revealed differentiation in human chromosomes. Chromosoma 44: 343–359.

    Google Scholar 

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Inhibition of Condensation in Human Chromosomes Induced by the Thymidine Analogue 5-iododeoxyuridine. Chromosome Res 6, 495–499 (1998). https://doi.org/10.1023/A:1009260714256

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