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Association between the Insertion/Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Angiopathy in Patients with Non-Insulin Dependent Diabetes Mellitus in Chuvash Republic

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Abstract

Insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene was analyzed in patients with non-insulin-dependent diabetes mellitus (NIDDM) and in the control group consisting of healthy subjects. The insertion allele (I) and genotype II were found to be associated with NIDDM. The frequencies of diabetic retinopathy and nephropathy in NIDDM patients were not associated with this polymorphism. However, an association was found between the DD genotype of the ACE gene and diabetic angiopathy in lower extremities.

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Authors and Affiliations

  1. Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia

    O. V. Miloserdova, P. A. Slominsky & S. A. Limborska

  2. Chuvash State University, Cheboksary, Chuvash Republic, 128 000, Russia

    I. V. Mauyanov & D. S. Markov

  3. Endocrinology Scientific Center, Russian Academy of Medical Sciences, Moscow, 119602, Russia

    M. I. Balabolkin

Authors
  1. O. V. Miloserdova
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  2. P. A. Slominsky
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  3. I. V. Mauyanov
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  4. D. S. Markov
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  5. M. I. Balabolkin
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  6. S. A. Limborska
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Miloserdova, O.V., Slominsky, P.A., Mauyanov, I.V. et al. Association between the Insertion/Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Angiopathy in Patients with Non-Insulin Dependent Diabetes Mellitus in Chuvash Republic. Russian Journal of Genetics 37, 98–101 (2001). https://doi.org/10.1023/A:1009082928603

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