Abstract
A Pd–Rh mixed metal catalytic system was developed that is able to hydrogenate 4-(phosphonomethyl)-2-pyridinecarboxylic acid to give 4-(phosphonomethyl)-2-piperidinecarboxylic acid with a cis selectivity of up to 98% with acceptable reaction time and without leading to metal contamination of the product.
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Steiner, H., Giannousis, P., Pische-Jacques, A. et al. Diastereoselective hydrogenation of 4-(phosphonomethyl)-2-pyridinecarboxylic acid. Topics in Catalysis 13, 191–194 (2000). https://doi.org/10.1023/A:1009069913798
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DOI: https://doi.org/10.1023/A:1009069913798