Abstract
The frequency of the GstM1 gene deletion homozygotes in eight populations of the Volga–Ural region belonging according to linguistic classification to Turkic (Bashkirs, Tatars, and Chuvashs), Finno–Ugric (Maris, Komis, Mordovians, and Udmurts), and Eastern–Slavic (Russians) ethnic groups, was examined by means of PCR technique. The frequency of the deletion homozygotes varied from 41.4% in Bashkirs to 61.3% in Mordovians. The mean deletion frequency comprised 50.1%, which was consistent with the data for European populations (χ2= 0.009).
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
Krynetskii, E.Yu., Polymorphism of Enzymes Involved in Drug Metabolism: Gene Structure and Enzymic Activity, Mol. Biol. (Moscow), 1996, vol. 30, no. 1, pp. 33-42.
Afanas'eva, I.S. and Spitsyn, V.A., Genetic Polymorphism of Liver Glutathione S-Transferase in Healthy Individuals and Patients with Alcohol-Induced Hepatitis, Genetika (Moscow), 1990, vol. 26, no. 7, pp. 1309-1315.
McLellan, R., Oscarson, M., Alexandrie, A.-K., et al., Characterization of a Human Glutathione S-Transferase μCluster Containing a Duplicated GSTM1 Gene That Causes Ultrarapid Enzyme Activity, Mol. Pharmacol., 1997, vol. 52, no. 6, pp. 958-965.
Xu, S., Wang, Y., Roe, B., et al., Characterization of the Human Class Mu Glutathione S-Transferase Gene Cluster and the GSTM1 Deletion, J. Biol. Chem., 1998, vol. 273, no. 6, pp. 3517-3527.
Anwar, W., Abdel-Rahman, S., El-Zein, R., et al., Genetic Polymorphism of GSTM1, CYP2E1, and CYP2D6 in Egyptian Bladder Cancer Patients, Carcinogenesis, 1996, vol. 17, no. 9, pp. 1923-1929.
Ambrosone, C., Freudenheim, J., Graham, S., et al., Cytochrome P4501A1 and Glutathione S-Transferase (M1) Genetic Polymorphisms and Postmenopausal Breast Cancer Risk, Cancer Res., 1995, vol. 55, no. 16, pp. 3483-3485.
Setiawan, V., Zhang, Z., Yu, G., et al., GSTT1 and GSTM1 Null Genotypes and the Risk of Gastric Cancer: A Case-Control Study in a Chinese Population, Cancer Epidemiol. Biomarkers Prev., 2000, vol. 9, no. 1, pp. 73-80.
Gao, Y. and Zhang, Q., Polymorphisms of the GSTM1 and CYP2D6 Genes Associated with Susceptibility to Lung Cancer in Chinese, Mutat. Res., 1999, vol. 444, no. 2, pp. 441-449.
Gertig, D.M., Stampfer, M., Haiman, C., et al., Glutathione S-Transferase GSTM1 and GSTT1 Polymorphisms and Colorectal Cancer Risk: A Prospective Study, Cancer Epidemiol. Biomarkers Prev.,1998, vol. 7, no. 11, pp. 1001-1005.
Baranov, V.S., Ivashchenko, T.E., Shved, N.Yu., et al., Genetic Factors Involved in Predisposition to and Therapy for Endometriosis, Genetika (Moscow), 1999, vol. 35, no. 2, pp. 243-248.
Chen, C., Madeleine, M.M., Lubinski, C., et al., Glutathione S-Transferase M1 Genotypes and the Risk of Anal Cancer: A Population-Based Case-Control Study, Cancer Epidemiol. Biomarkers Prev., 1996, vol. 5, no. 12, pp. 985-991.
Wienske, J.K., Wrensch, M.R., Miike, R., et al., Population-Based Study of Glutathione S-Transferase Mu Gene Deletion in Adult Glioma Cases and Controls, Carcinogenesis, 1997, vol. 18, no. 7, pp. 1431-1433.
Quinones, L., Berthou, F., Valera, N., et al., Ethnic Susceptibility to Lung Cancer: Differences in CYP2E1, CYP1A1, and GSTM1 Genetic Polymorphisms between French Caucasian and Chilean Populations, Cancer Lett. (Shannon, Irel.), 1999, vol. 141, nos. 1-2, pp. 167-171.
Kihara, M., Kihara, M., and Noda, K., Lung Cancer Risk of the GSTM1 Null Genotype Is Enhanced in the Presence of the GSTP1 Mutated Genotype in Male Japanese Smokers, Cancer Lett. (Shannon, Irel.), 1999, vol. 137, no. 1, pp. 53-60.
Chen, C., Madeleine, M.M., Weiss, N.S., et al., Glutathione S-Transferase M1 Genotypes and the Risk of Vulvar Cancer: A Population-Based Case-Control Study, Am. J. Epidemiol., 1999, vol. 150, no. 5, pp. 437-442.
Chen, C.L., Liu, Q., and Relling, M.V., Simultaneous Characterization of Glutathione S-Transferase M1 and T1 Polymorphisms by Polymerase Chain Reaction in American Whites and Blacks, Pharmacogenetics,1996, vol. 6, no. 2, pp. 187-191.
Arruda, V.R., Grignolli, C.E., Goncalves, M.S., et al., Prevalence of Homozygosity for the Deleted Alleles of Glutathione S-Transferase Mu (GSTM1) and Theta (GSTT1) among Distinct Ethnic Groups from Brazil: Relevance to Environmental Carcinogenesis?, Clin. Genet., 1998, vol. 54, no. 3, pp. 210-214.
Gawronska-Szklarz, B., Wojcicki, M., and Kuprianowicz, A., CYP2D6 and GSTM1 Genotypes in a Polish Population, Eur. J. Chin. Pharmacol., 1999, vol. 55, no. 5, pp. 389-392.
Mikelsaar, A.V., Tasa, G., Parlist, P., et al., Human Glutathione S-Transferase GSTM1 Genetic Polymorphism in Estonia, Hum. Hered., 1994, vol. 44, no. 5, pp. 248-251.
Nyberg, F., Hou, S.M., Hemminki, K., et al., Glutathione S-Transferase Mu 1 and N-Acetyltransferase-2 Genetic Polymorphisms and Exposure to Tobacco Smoke in Nonsmoking and Smoking Lung Cancer Patients and Population Controls, Cancer Epidemiol. Biomarkers Prev., 1998, vol. 7, no. 10, pp. 875-883.
Hong, Y.S., Chang, J.H., Kwon, O.J., et al., Polymorphism of the CYP1A1 and Glutathione S-Transferase Gene in Korean Lung Cancer Patients, Exp. Mol. Med., 1998, vol. 30, no. 4, pp. 192-198.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vakhitova, Y.V., Soultanaeva, Z.M., Viktorova, T.V. et al. Polymorphism of Human Glutatione S-Transferase Gene in the Populations of the Volga–Ural Region. Russian Journal of Genetics 37, 202–204 (2001). https://doi.org/10.1023/A:1009006308982
Issue Date:
DOI: https://doi.org/10.1023/A:1009006308982