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Evaluation of patient's Health-Related Quality of Life using a modified and shortened version of the Living With Asthma Questionnaire (ms-LWAQ) and the medical outcomes study, Short-Form 36 (SF-36)

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Abstract

Objective: The specific objectives of this study were to: 1) study the effect of moderate-to-severe asthma on patient's Health-Related Quality of Life (HRQoL) as measured by the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) and 2) evaluate the construct validity of a modified and shortened version of the Living With Asthma Questionnaire (ms-LWAQ) using the SF-36 as a concomitant measure of HRQoL. Methods: Cross-sectional, telephone or mail surveys of asthmatic patients enrolled in two central Florida managed care organizations. Results: All subscales of the SF-36 and four subscales of the ms-LWAQ demonstrated adequate reliability in this population (Cronbach α > 0.72). The subscales of the SF-36 most affected by patient's asthma were: general health perceptions, vitality and physical role functioning. These three subscales were correlated with four subscales of the ms-LWAQ: consequences, seriousness, affect and leisure. Six of the eight SF-36 subscales and all of the ms-LWAQ subscales were associated with patient's emergency department and hospital utilization. Conclusion: The ms-LWAQ and SF-36 are valid as useful measures of asthma patient's HRQoL in this cross-sectional study. Severity of disease, as measured by health care utilization, was significantly associated with HRQoL.

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Authors and Affiliations

  1. Department of Pharmacy Health Care Administration, College of Pharmacy, University of Florida, Gainesville, FL, Canada

    L. Douglas Ried

  2. Department of Behavioral and Administrative Pharmacy, School of Pharmacy, West Virginia University, Morgantown, WV, Canada

    David P. Nau

  3. Faculty of Pharmaceutical Sciences, Division of Pharmacy Practice, University of British Columbia, Vancouver, B.C., Canada

    Timothy J. Grainger-Rousseau

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  1. L. Douglas Ried
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  2. David P. Nau
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  3. Timothy J. Grainger-Rousseau
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Ried, L.D., Nau, D.P. & Grainger-Rousseau, T.J. Evaluation of patient's Health-Related Quality of Life using a modified and shortened version of the Living With Asthma Questionnaire (ms-LWAQ) and the medical outcomes study, Short-Form 36 (SF-36). Qual Life Res 8, 491–499 (1999). https://doi.org/10.1023/A:1008974406669

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