Abstract
The release of human growth hormone (GH) from bioartificial polymeric materials in the form of hydrogels, was measured in vitro for up to 3 weeks. Poly(vinyl-alcohol) (PVA) was blended, in different ratios, with two biological polymers, dextran and chitosan respectively. These blends were used to prepare hydrogels, using a freeze–thawing method. The hydrogels were loaded with GH, and their potential use as delivery systems was investigated. The release with time of PVA, in aqueous medium, was also monitored and evaluated. Scanning electron microscopy was used to investigate the structure of the hydrogels. The results obtained indicated that GH can be released from both dextran/PVA and chitosan/PVA hydrogels. The initial GH concentration used for sample loading affected the total quantity of GH released but not the pattern of release. The amount of GH released was affected by the content of the biological component. The percentage of PVA released was low but it was, however, related to the content of chitosan and dextran in the blends. ©1999 Kluwer Academic Publishers
Similar content being viewed by others
References
P. Giusti, L. Lazzeri and M. G. Cascone, ``The polymeric materials encyclopedia,'' (CRC Press, Boca Raton, FL, 1996).
P. Giusti, L. Lazzeri and L. Lelli, TRIP 1 (1993) 261.
L. Lazzeri, ibid. 4 (1996) 249.
M. Seggiani, L. Lazzeri, M. G. Cascone, N. Barbani, S. Vitolo and M. Palla, J. Mater. Sci.: Mater. Med. 5 (1994) 868.
L. Lazzeri, N. Barbani, L. Lelli, A. Bonaretti, P. Centonze, P. Giusti, in ``Proceeding of the 10th European Conference on Biomaterials,'' Davos, Switzerland, September 8–11, 1993, p. 78.
M. G. Cascone, B. Sim and S. Downes, Biomaterials 16 (1995) 569.
M. G. Cascone, L. Di silvio, B. Sim and S. Downes, J. Mater. Sci.: Mater. Med. 5 (1994) 770.
P. Giusti, L. Lazzeri, N. Barbani, P. Narducci, A. Bonaretti, M. Palla and L. Lelli, ibid. 4 (1993) 538.
L. Lazzeri, N. Barbani, M. G. Cascone, D. Lupinacci, P. Giusti and M. Laus, ibid. 5 (1994) 862.
R. Sbarbati del guerra, M. G. Cascone, N. Barbani and L. Lazzeri, ibid. 5 (1994) 613.
M. Nambu, Japanese Patent 82-130543, 1982.
E. Canalis, Clin. Orthop. Rel. Res. 193 (1985) 246.
A. C. Tanquary and R. E. Lacey, Adv. Exp. Med. Biol. 47 (1974).
S. Downes, D. J. Wood, A. J. Malcom and S. Y. Ali, Clin. Orth. Rel. Res. 252(1990) 294.
S. Downes, Clin. Mater. 7 (1991) 227.
S. Downes, M. V. Kayser, G. Blunnand S. Y. Ali, Cells Mater. 1 (1991) 171.
S. Downes, L. Di silvio, C. P. A. T. Klein and M. V. Kayser, J. Mater. Sci.: Mater. Med. 2 (1991) 176.
L. Di silvio, M. V. Kayser and S. Downes, Clin. Mater. 16 (1994) 91.
G. Morel, P. Chavassieux, P. M. Dubois, P. J. Meunier and G. Boivin, Cell Tissue Res. 273 (1993) 279.
M. Kassem, W. Blum, J. Ristelli, L. Mosekilde and E. F. Eriksen, Calcif. Tiss. Int. 52 (1993) 222.
R. A. A. Muzzarelli, M. Mattioli-belmonte, C. Tietz, R. Biagini, G. Ferioli, M. A. Brunelli, M. Fini, R. Giardino, P. Ilari and G. Biagini, Biomaterials 15 (1994) 1075.
S. Berrada, J. Amedee, T. Avramoglou, J. Jozefovicz and M. F. Harmand, J. Biomater. Sci. Polymer Edn. 6 (1994) 211.
D. C. Bujanda and A. Rubin, Polymer 25 (1984) 1759.
M. G. Cascone, S. Maltinti, N. Barbani and M. Laus, J. Mater. Sci.: Mater. Med. submitted.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cascone, M.G., Maltinti, S. Hydrogels based on chitosan and dextran as potential drug delivery systems. Journal of Materials Science: Materials in Medicine 10, 301–307 (1999). https://doi.org/10.1023/A:1008961614439
Issue Date:
DOI: https://doi.org/10.1023/A:1008961614439