Abstract
Objective: To assess the risk for melanoma associated with moles and pigmentary characteristics.
Methods: Representative melanoma cases (773) among non-Hispanic white residents under age 65 occurring between 1 June 1978 and 1 December 1983 in Los Angeles County were compared to controls (752) matched to cases by age, sex, race and neighborhood of residence. Factors considered include hair, eye, and skin color; numbers of freckles and moles; and propensity to burn and tan obtained during an in-person interview.
Results: Five hundred and fifty-one cases were classified as superficial spreading melanoma (SSM) and 110 as nodular melanoma (NM). For SSM, the important risk determinants were hair and skin color, freckling, and mole prevalence. Light skin and more freckles were found to be more highly associated with SSM for younger compared to older subjects, whereas the associations between SSM and both hair color and moles remained independent of age. NM showed patterns of risk similar to SSM with the exception of skin color. NM showed no evidence of increasing risk with lighter skin, as compared to the strong association seen for SSM.
Conclusion: Hair and skin color, freckling and, especially, numbers and size of moles are important determinants of melanoma risk.
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Garbe C, Kruger S, Stadler R, Guggenmoos-Holzmann I, Orfanos CE (1989) Markers and relative risk in a German population for developing malignant melanoma. Int J Dermatol 28: 517–523.
Grob JJ, Gouvernet J, Aymar D, et al. (1990) Count of benign melanocytic nevi as a major indicator of risk for nonfamilial nodular and superficial spreading melanoma. Cancer 66: 387–395.
Holly EA, Aston DA, Cress RD, Ahn DK, Kristiansen JJ (1995) Cutaneous melanoma in women. II. Phenotypic characteristics and other host-related factors. Am J Epidemiol 1995 141: 934–942.
Bataille V, Bishop JA, Sasieni P, et al. (1996) Risk of cutaneous melanoma in relation to the numbers, types and sites of naevi: a case-control study. Br J Cancer 73: 1605–1611.
Grulich AE, Bataille V, Swerdlow AJ, et al. (1996) Naevi and pigmentary characteristics as risk factors for melanoma in a high-risk population: a case-control study in New South Wales, Australia. Int J Cancer 67: 485–491.
Tucker MA, Halpern A, Holly EA, et al. (1997) Clinically recognized dysplastic nevi. A central risk factor for cutaneous melanoma. JAMA 277: 1439–1444.
Bliss JM, Ford D, Swerdlow AJ, et al. (1995) Risk of cutaneous melanoma associated with pigmentation characteristics and freckling: systematic overview of 10 case-control studies. The International Melanoma Analysis Group (IMAGE). Int J Cancer 1995 62: 367–376.
Elwood JM, Jopson J (1997) Melanoma and sun exposure: an overview of published studies. Int J Cancer 73: 198–203.
Mack TM (1977) Cancer surveillance program in Los Angeles County. Natl Cancer Inst Monogr 47: 99–101.
McGovern VJ, Mihm MC Jr, Bailly C, et al. (1973) The Classiffication of malignant melanoma and its histologic reporting. Cancer 32: 1446–1457.
Elder DE, Ainsworth AM, Clark WH (1979) The surgical pathology of cutaneous malignant melanoma. In: Clark WH, Goldman LI, Mastrangelo MJ, eds. Human Malignant Melanoma. New York: Grune & Stratton, pp. 55–108.
Fitzpatrick TB, Pathak MA, Parrish JA (1974) Protection of the human skin against the effects of the sunburn ultraviolet (290-320 nm). In: Fitzpatrick TB, ed. Sunlight and Man: Normal and Abnormal Photobiotic Responses. Tokyo: Tokyo Press, pp. 751–765.
Breslow NE, Day DE (1980) Statistical Methods in Cancer Research, vol. 1: The Analysis of Case-Control Studies. Lyon: International Agency for Research on Cancer.
Osterlind A, Tucker MA, Hou-Jensen K, Stone BJ, Engholm G, Jensen OM (1988) The Danish case-control study of cutaneous malignant melanoma. I. Importance of host factors. Int J Cancer 42: 200–206.
Cristofolini M, Franceschi S, Tasin L, et al. (1987) Risk factors for cutaneous malignant melanoma in a northern Italian population. Int J Cancer 39: 150–154.
Beral V, Evans S, Shaw H, Milton G (1983) Cutaneous factors related to the risk of malignant melanoma. Br J Dermatol 109: 165–172.
Dubin N, Moseson M, Pasternack BS (1986) Epidemiology of malignant melanoma: pigmentary traits. ultraviolet radiation, and the identification of high-risk populations. Rec Results Cancer Res 102: 56–75.
Green A, Siskind V, Bain C, Alexander J (1985) Sunburn and malignant melanoma. Br J Cancer 51: 393–397.
Holman CD, Armstrong BK (1984) Pigmentary traits, ethnic origin, benign nevi, and family history as risk factors for cutaneous malignant melanoma. J Natl Cancer Inst 72: 257–266.
Elwood JM, Williamson C, Stapleton PJ (1986) Malignant melanoma in relation to moles, pigmentation, and exposure to fluorescent and other lighting sources. Br J Cancer 53: 65–74.
Elwood JM, Whitehead SM, Davison J, Stewart M, Galt M (1990) Malignant melanoma in England: risks associated with naevi, freckles, social class, hair colour, and sunburn. Int J Epidemiol 19: 801–810.
Andreassi L, Simoni S, fiorini P, Fimiani M (1987) Phenotypic characters related to skin type and minimal erythemal dose. Photo-Dermatology 4: 43–46.
Rampen FH, Fleuren BA, de Boo TM, Lemmens WA (1988) Unreliability of self-reported burning tendency and tanning ability. Arch Dermatol 124: 885–888.
Holly EA, Kelly JW, Shpall SN, Chiu SH (1987) Number of melanocytic nevi as a major risk factor for malignant melanoma. J Am Acad Dermatol 17: 459–468.
Walter SD, Marrett LD, From L, Hertzman C, Shannon HS, Roy P (1990) The association of cutaneous malignant melanoma with the use of sunbeds and sunlamps. Am J Epidemiol 131: 232–243.
Masback A, Westerdahl J, Ingvar C, Olsson H, Jonsson N (1999) Clinical and histopathological characteristics in relation to aetiological risk factors in cutaneous melanoma: a population-based study. Melanoma Res 9: 189–197.
Gallagher RP, Elwood JM, Hill GB (1986) Risk factors for cutaneous malignant melanoma: the Western Canada Melanoma Study. Rec Results Cancer Res 102: 38–55.
Swerdlow AJ, English J, MacKie RM, et al. (1986) Benign melanocytic naevi as a risk factor for malignant melanoma. Br Med J Clin Res Ed 292: 1555–1559.
Dabkowski J, Omulecki A, Zalewska A (1997) Identification of melanoma risk factors in the Polish population. Dermatol Surg 23: 1039–1042.
Green A, MacLennan R, Siskind V (1985) Common acquired naevi and the risk of malignant melanoma. Int J Cancer 35: 297–300.
US Environmental Protection Agency (1987) Assessing the Risks of Strospheric Ozone Depletion: Washington, DC.
Chedekel MR, Post PW, Deibel RM, Kalus M (1977) Photodestruction of phaeomelanin. Photochem Photobiol 26: 651–653.
Elwood JM, Gallagher RP, Worth AJ, Wood WS, Pearson JC (1987) Etiological differences between subtypes of cutaneous malignant melanoma: Western Canada Melanoma Study. J Nat Cancer Inst 78: 37–44.
Sorahan T, Grimley RP (1985) The aetiological significance of sunlight and fluorescent lighting in malignant melanoma: a case-control study. Br J Cancer 52: 765–769.
Bain C, Colditz GA, Willett WC, et al. (1988) Self-reports of mole counts and cutaneous malignant melanoma in women: methodological issues and risk of disease. Am J Epidemiol 127: 703–712.
Osterlind A, Tucker MA, Stone BJ, Jensen OM (1988) The Danish case-control study of cutaneous malignant melanoma. III. Hormonal and reproductive factors in women. Int J Cancer 42: 821–824.
Weinstock MA, Colditz GA, Willett WC, et al. (1989) Moles and site-specific risk of nonfamilial cutaneous malignant melanoma in women. J Natl Cancer Inst 81: 948–952.
Rodenas JM, Delgado-Rodriguez M, Farinas-Alvarez C, Herranz MT, Serrano S (1997) Melanocytic nevi and risk of cutaneous malignant melanoma in southern Spain. Am J Epidemiol 145: 1020–1029.
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Langholz, B., Richardson, J., Rappaport, E. et al. Skin characteristics and risk of superficial spreading and nodular melanoma (United States). Cancer Causes Control 11, 741–750 (2000). https://doi.org/10.1023/A:1008952219416
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DOI: https://doi.org/10.1023/A:1008952219416