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Parental occupational exposures and risk of neuroblastoma: a case–control study (United States)

Abstract

Background: A case–control study was conducted with 183 histologically confirmed neuroblastoma cases aged 0–14 years diagnosed among residents of New York State, excluding New York City, between 1976 and 1987. Three hundred seventy-two controls were selected from the New York State live birth certificate registry and were matched to cases on year of birth.

Methods: Parental occupational exposures at the time of each child's birth were obtained from maternal telephone interviews, successfully completed for 85% of cases and 87% of controls.

Results: Odds ratios were significantly elevated for maternal occupation in the service (OR = 2.0, 95% CI = 1.0–4.1) and retail (OR = 2.0, 95% CI = 1.1–3.7) industries and paternal occupation in materials handling (OR = 3.8, 95% CI = 1.1–14.6). Odds ratios were also significantly elevated for maternal report of occupational exposure to acetone (OR = 3.1, 95% CI = 1.7–5.6), insecticides (OR = 2.3, 95% CI = 1.4–3.7), lead (OR = 4.7, 95% CI = 1.3–18.2) and petroleum (OR = 3.0, 95% CI = 1.5–6.1) and paternal exposure to creosote (OR = 2.1, 95% CI = 1.1–4.3), dioxin (OR = 6.9, 95% CI = 1.3–68.4), lead (OR = 2.4, 95% CI = 1.2–4.8), and petroleum (OR = 1.8, 95% CI = 1.1–2.8).

Conclusions: Due to the uncertainty of the biologic plausibility of these associations and the possibility of alternative explanations, these results should be interpreted cautiously.

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Kerr, M.A., Nasca, P.C., Mundt, K.A. et al. Parental occupational exposures and risk of neuroblastoma: a case–control study (United States). Cancer Causes Control 11, 635–643 (2000). https://doi.org/10.1023/A:1008951632482

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  • case–control
  • neuroblastoma
  • parental occupational exposure