Abstract
A new antifungal antibiotic, HA-1-92, was isolated from the biomass of Streptomyces CDRIL-312, by extracting in butanol and further purified by silica gel column chromatography followed by preparative TLC. The antibiotic is presumed to be an oxohexaene macrolide and showed promising antifungal activity against yeasts and filamentous fungi including human and plant pathogens. It was found to be less toxic in mice than known oxohexaenes.
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Harindran, J., Gupte, T. & Naik, S. HA-1-92, A new antifungal antibiotic produced by Streptomyces CDRIL-312: Fermentation, isolation, purification and biological activity. World Journal of Microbiology and Biotechnology 15, 425–430 (1999). https://doi.org/10.1023/A:1008934808486
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DOI: https://doi.org/10.1023/A:1008934808486