Abstract
Different methods have been proposed to reduce the surface thrombogenicity of small caliber vascular grafts, using plasma treatments of polymer surfaces in order to improve the adhesion and the proliferation of human endothelial cells (HEC). Plasma modified polyethyleneterephthalate (PET) substrates were employed to grow HEC, isolated from the umbilical vein. A combination of X-ray photoelectron spectroscopy (XPS) and Sessile contact angle (SCA) measurements allowed the study of the surface modifications produced soon after nitrogen and hydrogen plasma treatments with respect to an untreated PET substrate, used as reference. It was possible to select a number of PET substrates while actually performing the HEC seeding experiments. The HEC proliferation was evaluated by light microscope image analyzes. ©2000 Kluwer Academic Publishers
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References
F. HESS, Microsurgery 6 (1985) 59.
Y. OKADA, K. KUMADA, T. TERACHI, K. NISHIMURA, T. TOMOYOSHI and O. YOSHIDA, J. Urol. 155 (1996) 444.
A. D. CALLOW, “Historical overview of experimental and clinical development of vascular grafts in biological and synthetic vascular prostheses”, edited by J. C. Stanley, W. E. Burkel, S. M. Sindenauer, R. H. Bartlett and J. G. Turcotte (Grune Stratton, New York, 1982) p. 11.
P. B. VAN WACHEM, C. M. VRERIKS, T. BEUGELING, J. FEIJEN, A. BANTJES, J. P. DETMERS and W. G. VAN AKEN, J. Biomed. Mater. Res. 21 (1987) 701.
S. K. WILLIAMS, B. E. JARRELL, L. FRIEND, J. S. RADOMSKI, R. A. CARABASI, E. A. KOOLPE, S. N. MUELLER, T. MARIANUCCI and E. SEVINE, J. Surgery Res. 38 (1985) 618.
S. I. ERTEL, B. D. RATNER and T. A. HORBETT, J. Biomed. Mater. Res. 24 (1990) 1637.
P. FAVIA, M. V. STENDARDO and R. D'AGOSTINO, Plasmas and Polymers 1 (1996) 91.
R. D'AGOSTINO (ed.), “Plasma deposition, treatment and etching of polymers” (Academic Press, Boston 1990).
W. R. GOMBOTZ and A. S. HOFFMAN, “CRC Critical reviews in biocompatibility gas discharge techniques for biomaterials modifications” (CRC Press 1987) p. 1.
B. D. RATNER, J. Biomaterials Sci: Pol. Ed. 4 (1992) 61.
F. AREFI, M. TATOULIAN, V. ANDRE, J. AMOUROUX and G. LORANG, “Metallized plastics 3: fundamental and applied aspects”, edited by K.L. Mittal (M. Dekker Publisher, New York, 1992).
D. YOUXIAN, H. J. GRIESSER, A. W. H. MAU, R. SCHMIDT and J. LIESEGANG, Polymer 32 (1991) 1126.
H. J. GRIESSER, R. C. CHATELIER, T. R. GENGENBACH, G. JOHNSON and J. STEELE, J. Biomat. Sci Polymer Ed 5 (1994) 531.
E. A. JAFFE, R. L. NACHMAN, C. G. BECHER and C. R. MINICK, J. Clin. Invest. 52 (1973) 2745.
A. DEKKER, K. REITSMA, T. BEUGELING, T. BANTJES, J. FEIJEN and W. G. VAN AKEN, Biomat. 12 (1991) 130.
Y. TAMADA and Y. IKADA, Polymer 34 (1993) 2208.
N. JENSEN, B. SINDBLAD and D. BERGVIST, Eur. Surg. Res. 28 (1996) 49.
T. L. FOXALL, K. R. AUGER, A. D. CALLOW and P. LIBBY, J. Surg. Res. 41 (1986) 158.
J. S. ANDERSON, T. M. PRICE, S. R. HANSON and S. A. HARKER, Surgery 101 (1987) 577.
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Mirenghi, L., Ramires, P., Pentassuglia, R.E. et al. Growth of human endothelial cells on plasma-treated polyethyleneterephthalate surfaces. Journal of Materials Science: Materials in Medicine 11, 327–331 (2000). https://doi.org/10.1023/A:1008929902205
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DOI: https://doi.org/10.1023/A:1008929902205