Abstract
Some recent excellent papers on the electrochemical treatment (ECT) of tumors provide observations for an analysis of this phenomenon from an electrochemical point of view. An attempt is made here to develop the idea that ECT is a case of electro-osmotic dewatering (EOD) of the tumor material with the consequent changes in pH, with the concomitant role of reactions at the electrodes. Some quantitative considerations explaining the role of electrochemical double layers, zeta potential and associated quantities during the electro-osmotic process are outlined. A capsule summary of the factors that may be involved in necrosis of the tumor tissue is given in which the electro-osmotic dewatering at the anode and excess water accumulation at the cathode are the paramount effects, together with the associated pH changes. © 1999 Kluwer Academic Publishers
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References
B. NordenstroÖm, “Biologically-closed electric circuits” (Nordic Medical Publications, Stockholm, 1983).
Idem., J. Bioelectr. 3 (1984) 137.
Idem., Ann. Radiol. 28 (1985) 128.
Idem., IRCS 6 (1987) 537.
Idem., Eur. J. Surg. Suppl. 574 (1994) 93.
C. K. Chou, Bioelectromagnetics 18 (1997) 1.
K. H. Li, Y. L. Xin, Y. N. Gu and B. L. Xu, ibid. 18 (1997) 2.
C. K. Chou, J. A. Mcdougall, C. Ahn and N. Vora, ibid. 18 (1997) 14.
Y. L. Xin, F. S. Xue, B. S. Ge, F. R. Zhao, B. Shi and W. Zhang, ibid. 18 (1997) 8.
J. O'M. Bockris and A. K. N. Reddy, “Modern electrochemistry”, Vol. 1 and 2 (Plenum Press, New York, 1970).
J. O'M. Bockris and S. U. M. Khan, “Surface electrochemistry”, (Plenum Press, New York, 1993).
A. K. Vijh, “The electrochemistry of metals and semiconductors”, (Marcel Dekker, New York, 1973).
Idem., in “Modern aspects of electrochemistry”, Vol. 17, edited by J. O'M. Bockris, B. E. Conway and R.W. White (Plenum Press, New York 1986).
Idem., Drying Technology-An International Journal 13 (1995) 215.
Idem., in “Modern aspects of electrochemistry”, Vol. 32, edited by B. E. Conway, J. O'M. Bockris and R. E. White (Plenum Press, New York, 1999).
R. E. Lafond, “Cancer: the outlaw cell”, 2nd edition (American Chemical Society, Washington, 1988).
R. K. Jain, Sci. Amer. 271 (1994) 58.
S. Ohki, in “Comprehensive treatise of electrochemistry”, Vol. 10, edited by S. Srinivasan, Y. A. Chizmadzhev, J. O'M. Bockris, B. E. Conway and E. Yeager (Plenum Press, New York, 1985).
B. E. Conway, “Theory and principles of electrode processes”, (Ronald Press, New York, 1965).
D. H. Everett, “Basic principles of colloid science”, (The Royal Society of Chemistry, London, 1988).
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Vijh, A.K. Electrochemical field effects in biological materials: electro-osmotic dewatering of cancerous tissue as the mechanistic proposal for the electrochemical treatment of tumors. Journal of Materials Science: Materials in Medicine 10, 419–423 (1999). https://doi.org/10.1023/A:1008927114924
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DOI: https://doi.org/10.1023/A:1008927114924