Objectives: Epidemiological evidence suggests that dietary factors can play a role in the etiology of prostate cancer. Results from several case–control and cohort studies on nutrient intake and prostate cancer have been unclear. The authors examined the effect of lipid intake on the risk of prostate cancer.
Methods: In order to assess associations between lipid intake and prostate cancer risk, a case–control study was conducted between May 1994 and March 1998 in the Barcelona metropolitan area, Spain. Two hundred seventeen incident cases with histologically confirmed diagnosis of prostate cancer were matched to 434 hospital and community controls by age and residence. Information about food intake was gathered by a semiquantitative food-frequency questionnaire. Unconditional logistic regression was used for the analysis.
Results and conclusions: Animal fat intake was associated with prostate cancer with an estimated OR for highest quartile of 2.0 (95% CI 1.2–3.2). Vitamin C intake was inversely associated with prostate cancer (OR = 0.6; 95% CI 0.3–0.9). The prostate cancer risk increased in proportion to α-linolenic acid intake. In the analysis adjusting for energy and major covariables the estimated OR for upper quartile of α-linolenic acid was 3.1 (95% CI 1.1–3.8). In conclusion, the association between fat intake and prostate cancer may be correlated with α-linolenic acid, although the specific mechanism has to be determined.
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Nomura AM, Kolonel LN (1991) Prostate cancer: a current perspective. Epidemiol Rev. 13: 200–227.
Checkoway H, DiFerdinando G, Hulka BS, Mickey DD (1987) Medical, life-style and occupational risk factors for prostate cancer. Prostate 10: 79–88.
Dishi K, Okada K, Yoshida O, et al. (1990) A case-control study of prostatic cancer in Kyoto, Japan: sexual risk factors. Prostate 17: 269–279.
Honda GD, Bernstein L, Ross RK, Greenland S, Gerkins V, Henderson BE (1988) Vasectomy, cigarette smoking and age at first sexual intercourse as risk factors for prostate cancer in middle-age men. Br J Cancer 57: 326–331.
Miettlin C, Natarajan N, Huben R (1990) Vasectomy and prostate cancer risk. Am J Epidemiol. 132: 1056–1061.
Rosenberg L, Palmer JR, Zauber AC, Warshauer ME, Stolley PR, Shapiro S (1990) Vasectomy and the risk of prostate cancer. Am J Epidemiol. 132: 1051–1055.
Pienta KJ, Esper PS (1993) Risk factors for prostate cancer. Ann Intern Med. 118: 793–803.
Kolonel LN (1996) Nutrition and prostate cancer. Cancer Causes Control 7: 83–94.
Hursting SD, Thornquist M, Henderson MM (1990) Types of dietary fat and the incidence of cancer in five site. Prev Med. 19: 242–253.
Kolonel LN, Nomura AM, Cooney RV (1999) Dietary fat and prostate cancer: current status. J Natl Cancer Inst. 91: 414–428.
Willett WC (1997) Specific fatty acids and risk of breast and prostate cancer: dietary intake. Am J Clin Nutr. 66: (Suppl.) 1557S–1563S.
West DW, Slattery ML, Robinson LM, French TK, Mahoney AW (1991) Adult dietary intake and prostate cancer risk in Utah: a case-control study with special reference to aggressive tumors. Cancer Causes Control 2: 85–94.
Anderson SO, Wolk A, BergstrÖm R, et al. (1996) Energy, nutrient intake and prostate cancer risk: a population-based case-control study in Sweden. Int J Cancer 68: 716–722.
Godley PA, Campbell MK, Gallagher P, Martinson FE, Motiler JL, Sanders RS (1996) Biomarkers of essential fatty acid con-sumption and risk of prostatic carcinoma. Cancer Epidemiol Biomarkers Prev. 5: 898–895.
Harvei S, Bjewe KS, Tretli S, Jellmi E, Robsahim TE, Vatten L (1997) Prediagnostic level of fatty acids in serum phospholipids: omega-3 and omega-6 fatty acids and the risk of prostate cancer. Int J Cancer 71: 545–551.
Giovannucci E, Rimm EB, Colditz GA, et al. (1993) A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst. 85: 1571–1579.
Gann PH, Hennekens CH, Sacks FM, Grodstein F, Giovannucci E, Stampfer MJ (1994) Prospective study of plasma fatty acids and risk of prostate cancer. J Natl Cancer Inst 86: 281–286.
Rose DP (1997) Dietary fatty acids and prevention of hormone response cancer. Proc Soc Exp Biol Med 216: 224–233.
Robinson LL, Doigle A (1984) Control election using random digit dialing for cases of childhood cancer. Am J Epidemiol 120: 164–166.
Ramon JM, Serra LL, Cerdo C, Oromi J (1993) Dietary factors and gastric cancer risk: a case-control study in Spain. Cancer 71: 1731–1735.
Mataix J, Maáas M, Llopis J, Martinez E (1995) Tablas de composición de alimentos espaáoles. Instituto de Nutrición y Tecnología de los Alimentos. Granada: Universidad de Granada.
Hepburn FN, Exler J, Weihrauch J (1986) Provisional tables on the content of omega3 fatty acids and other fat components of selected foods. J Am Diet Assoc 96: 783–788.
Vilardell F, Portero M, Aragón M, Bellmunt MJ, Pamplona R, Prat J (1995) Fatty acids composition of fish commonly consumed in the Spanish diet. Diet and marine lipids. Clin Invest Arteriosesclerosis 7: 45–51.
Willett WC, Stampfer MJ (1986) Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 124: 17–27.
Whittemore AS, Kolonel LN, Wu AH, et al. (1995) Prostate cancer in relation to diet, physical activity and body size in blacks, whites and Asians in the United States and Canada. J Natl Cancer Inst 87: 652–661.
Marchand L, Kolonel LN, Wilkens LR, Myers BE, Hirohata T (1994) Animal fat consumption and prostate cancer: a prospective study in Hawaii. Epidemiology 5: 276–282.
Hortge P, Brinton LA, Rosenthal JF, et al. (1988) Random digit dialling in selecting a population-based control group. Am J Epidemiol 120: 825–833.
Graham S, Hangley B, Marshall J, et al. (1983) Diet in the epidemiology of carcinoma of prostate gland. J Natl Cancer Inst 70: 687–692.
Bravo MP, Castellanos E, Del Rey J (1991) Dietary factors and prostatic cancer. Urol Int 46: 163–166.
Walker AR, Walker BF, Tsotetsi NG, Sebitso C, Siwedi D, Walker AJ (1992) A case-control study of prostate cancer in black patients in Soweto, South Africa. Br J Cancer 65: 438–441.
Ohno Y, Yoshida O, Oishi K, Okada K, Yamabe H, Schroeder FH (1988) Dietary beta-carotene and cancer of the prostate: a case-control study in Kyoto, Japan. Cancer Res 48: 1331–1336.
Mettlin C, Selenskas S, Natarajan N, Huben R (1989) Beta-carotene and animal fats and their relationship to prostate cancer risk. A case-control study. Cancer 64: 605–612.
Rohan TE, Howe GR, Burch JD, Jain M (1995) Dietary factors and risk of prostate cancer: a case-control study in Ontario, Canada. Cancer Causes Control 6: 145–154.
Ghadirian P, Lacroix A, Maisonneuve P, et al. (1996) Nutritional factors and prostate cancer: a case-control study of French-Canadians in Montreal, Canada. Cancer Causes Control 7: 428–436.
Key TJ, Silcocks PB, Davey GK, Appleby PN, Bishop DT (1997) A case-control study of diet and prostate cancer. Br J Cancer 76: 678–687.
Veirod MB, Laake P, Thelle DS (1997) Dietary fat intake and risk of prostate cancer: a prospective study of 25708 Norwergian men. Int J Cancer 73: 634–638.
Schuurman AG, van den Brent PA, Dorant E, Goldbohm RA (1999) Animal products, calcium and protein and prostate cancer risk in the Netherlands cohort study. Br J Cancer 80: 1107–1113.
Giovannucci E (1995) Epidemiologic characteristics of prostate cancer. Cancer 75: 1766–1777.
Heinonen OP, Albanes D, Virtamo J, et al. (1998) Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. J Natl Cancer Inst 90: 440–446.
Chan JM, Stampfer MJ, Giovannucci E (1998) What causes prostate cancer? A brief summary of the epidemiology. Semin Cancer Biol 8: 263–273.
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Ramon, J.M., Bou, R., Romea, S. et al. Dietary fat intake and prostate cancer risk: a case–control study in Spain. Cancer Causes Control 11, 679–685 (2000). https://doi.org/10.1023/A:1008924116552
- animal fat intake
- lipid intake
- prostate cancer
- vitamin C