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Diet and benign ovarian tumors (United States)

Cancer Causes & Control volume 11, pages 389–401 (2000)Cite this article

Abstract

Objectives: The relation between benign ovarian tumors (BOTs) and nutrients, primarily dietary fat, was examined using case–control data.

Methods: 746 cases were diagnosed from 1 January 1992 to 31 December 1993. The 404 age- and hospital frequency-matched community controls were identified by random digit dialing. Six hundred seventy-three cases and 351 controls provided dietary information.

Results: The risk of BOTs was elevated for the highest vs. lowest quartile of intake of total, vegetable, saturated, monounsaturated, and polyunsaturated fat. The corresponding age-, hospital-, total energy-, and body mass index-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) are 1.3 (0.9–1.9), 1.7 (1.2–2.5), 1.2 (0.8–1.8), 1.3 (0.9–1.8), and 1.6 (1.1–2.3). After adjustment for polyunsaturated fat, the risk of BOTs only remained elevated for vegetable fat (highest vs. lowest quartile OR and 95% CI = 1.4 (0.8–2.3)). Elevated risks were observed for higher intakes of polyunsaturated fat with endometrioid, serous, and teratoma tumors. Higher intakes of vegetable fat, adjusted for polyunsaturated fat, increased the risk of endometrioid, mucinous, and serous tumors. Only the risk of serous BOTs was consistently lower for higher intakes of micronutrients, with the strongest reduction observed for sources of vitamin A. Estimates were not confounded by non-nutrient covariates.

Conclusions: Polyunsaturated and vegetable fat may increase the risk of BOTs, while vitamin A may lower the risk of serous BOTs; however, these findings and lack of associations for other nutrients should be replicated.

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Authors and Affiliations

  1. Division of Environmental Health Science, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1057, New York, NY, 10029, USA

    Julie A. Britton

  2. Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY, USA

    Carolyn Westhoff

  3. Division of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, New York, NY, USA

    Carolyn Westhoff, Geoffrey Howe & Marilie D. Gammon

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  1. Julie A. Britton
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  2. Carolyn Westhoff
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  3. Geoffrey Howe
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  4. Marilie D. Gammon
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Britton, J.A., Westhoff, C., Howe, G. et al. Diet and benign ovarian tumors (United States). Cancer Causes Control 11, 389–401 (2000). https://doi.org/10.1023/A:1008921710400

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  • DOI: https://doi.org/10.1023/A:1008921710400

  • case–control studies
  • diet
  • nutrition
  • ovarian neoplasms
  • risk factors