Cancer Causes & Control

, Volume 11, Issue 1, pp 1–8 | Cite as

Western diet, family history of colorectal cancer, NAT2, GSTM-1 and risk of colon cancer

  • M.L. Slattery
  • J.D. Potter
  • K.-N. Ma
  • B.J. Caan
  • M. Leppert
  • W. Samowitz

Abstract

Objective: In this study we examine the combined effects of Western diet, age at diagnosis, and genetic susceptibility.

Methods: We use data collected as part of an incident case–control study of colon cancer. Family history of colorectal cancer, N-acetyltransferase (NAT2), and gluathione-S-transferase (GSTM-1) are studied with Western diet and age at diagnosis.

Results: A significant interaction between age at time of diagnosis, Western dietary pattern, and family history of colorectal cancer (p for interaction = 0.03) was detected. Those with a family history of colorectal cancer who ate a predominantly Western diet were at increased risk of colon cancer (OR 14.0, 95% CI 3.9–50.1 for ≤55 years; OR 7.7, 95% CI 2.0–29.1 for 56–66 years; OR 1.6, 95% CI 0.8–3.2 for ≥67 years) compared to those without a family history of colorectal cancer and low levels of a Western diet. Associations with the Western diet were stronger than individual components of the dietary pattern. Neither NAT2 nor GSTM-1 showed significant interaction with Western diet.

Conclusion: The extent to which diet comprising a Western dietary pattern influences risk of colon cancer is dependent on age. This dietary pattern also appears to modulate the colon cancer risk associated with a family history of colon cancer.

colon neoplasia dietary pattern GSTM-1 meat NAT2 refined grains 

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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • M.L. Slattery
    • 1
  • J.D. Potter
    • 2
  • K.-N. Ma
    • 1
  • B.J. Caan
    • 3
  • M. Leppert
    • 4
  • W. Samowitz
    • 5
  1. 1.Department of Family and Preventive MedicineUniversity of Utah School of MedicineSalt Lake CityUSA
  2. 2.Fred Hutchinson Cancer Research Center, SeattleWashingtonUSA
  3. 3.Division of ResearchKaiser Permanente Medical Care ProgramOaklandUSA
  4. 4.Department of Human GeneticsUniversity of Utah School of MedicineSalt Lake CityUSA
  5. 5.Department of PathologyUniversity of Utah School of MedicineSalt Lake CityUSA

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