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Leptin and insulin growth factor I in relation to breast cancer (Greece)

Abstract

Objectives: Because both breast cancer and the hormone leptin are associated with obesity and reproductive phenomena in women, we have examined whether there is a relationship between leptin and breast cancer among premenopausal and postmenopausal women. We have also evaluated in this dataset the association of IGF-I with breast cancer.

Methods: Seventy-five cases, diagnosed during mammographic screening, with incident breast cancer were matched for age and type of permanent residence with seventy-five controls from those screened negative in the same study base.

Results: There was no evidence for an association between IGF-I and either premenopausal or postmenopausal breast cancer risk or between leptin and postmenopausal breast cancer. Among premenopausal women, however, there was a strong and statistically significant inverse association of leptin with breast cancer.

Conclusion: We did not confirm the positive association, reported from other investigations, of IGF-I with premenopausal breast cancer risk. We have found evidence, however, that leptin may be inversely related to breast cancer risk among premenopausal women. The latter finding is not biologically implausible and deserves to be examined in additional datasets.

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References

  1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425–432.

    Google Scholar 

  2. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P (1995) Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546–549.

    Google Scholar 

  3. Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS (1995) Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1: 1311–1314.

    Google Scholar 

  4. Maffei M, Halaas J, Ravussin E, et al. (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1: 1155–1161.

    Google Scholar 

  5. Caro JF, Sinha MK, Kolaczynski JW, Zhang PL, Considine RV (1996) Leptin: the tale of an obesity gene. Diabetes 45: 1455–1462.

    Google Scholar 

  6. Tritos NA, Mantzoros CS (1997) Leptin: its role in obesity and beyond. Diabetologia 40: 1371–1379.

    Google Scholar 

  7. Montague CT, Farooqi IS, Whitehead JP (1997) Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387: 903–908.

    Google Scholar 

  8. Garcia-Mayor RV, Andrade MA, Rios M, Lage M, Dieguez C, Casanuera FF (1997) Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage. J Clin Endocrinol Metab 82: 2849–2855.

    Google Scholar 

  9. Mantzoros CS, Flier JS, Rogol AD (1997) A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. J Clin Endocrinol Metab 82: 1066–1070.

    Google Scholar 

  10. Barash IA, Cheung CC, Weigle DS (1996) Leptin is a metabolic signal to the reproductive system. Endocrinology 137: 3144–3147.

    Google Scholar 

  11. Matkovic V, Ilich JZ, Skugor M, et al. (1997) Leptin is inversely related to age at menarche in human females. J Clin Endocrinol Metab 82: 3239–3245.

    Google Scholar 

  12. Hardie L, Trayhurn P, Abramovich D, Fowler P (1997) Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clin Endocrinol 47: 101–106.

    Google Scholar 

  13. Kelsey JL (1993) Breast cancer epidemiology: summary and future directions. Epidemiology 15: 256–263.

    Google Scholar 

  14. Lipworth L (1995) Epidemiology of breast cancer. Eur J Cancer Prev 4: 7–30.

    Google Scholar 

  15. Mantzoros CS, Bolhke K, Moschos S, Cramer DW (1999) Leptin in relation to carcinoma in situ of the breast: a study of premenopausal cases and controls. Int J Cancer 80: 523–526.

    Google Scholar 

  16. Bohlke K, Cramer DW, Trichopoulos D, Mantzoros CS (1998) Insulin-like growth factor-I in relation to premenopausal ductal carcinoma in situ of the breast. Epidemiology 9: 570–573.

    Google Scholar 

  17. Peyrat JP, Bonneterre J, Hecquet B, et al. (1993) Plasma insulin-like growth factor-I (IGF-I) concentrations in human breast cancer. Eur J Cancer 29A: 492–497.

    Google Scholar 

  18. Bruning PF, Van Doorn J, Bonfrer JM, et al. (1995) Insulin-like growth-factor-binding protein 3 is decreased in early-stage operable pre-menopausal breast cancer. Int J Cancer 62: 266–270.

    Google Scholar 

  19. Hankinson SE, Willett WC, Conditz GA, et al. (1998) Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 351: 1393–1396.

    Google Scholar 

  20. Mantzoros CS, Tzonou A, Signorello LB, Stampfer M, Trichopoulos D, Adami H-O (1997) Insulin-like growth factor I in relation to prostate cancer and benign prostatic hyperplasia. Br J Cancer 76: 1115–1118.

    Google Scholar 

  21. Chan JM, Stampfer MJ, Giovannucci E, et al. (1998) Circulating insulin-like growth factor-1 and prostate cancer risks: a prospective study. Science 279: 563–566.

    Google Scholar 

  22. Wolk A, Mantzoros CS, Andersson SO, et al. (1998) Insulin-like growth factor 1 and prostate cancer risk: a population-based, case-control study. J Natl Cancer Inst 90: 911–915.

    Google Scholar 

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Petridou, E., Papadiamantis, Y., Markopoulos, C. et al. Leptin and insulin growth factor I in relation to breast cancer (Greece). Cancer Causes Control 11, 383–388 (2000). https://doi.org/10.1023/A:1008903727238

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  • DOI: https://doi.org/10.1023/A:1008903727238

  • breast cancer
  • insulin growth factor I
  • leptin
  • postmenopause
  • premenopause