Journal of Computational Neuroscience

, Volume 6, Issue 2, pp 99–120 | Cite as

Frequency Change Detection in Human Auditory Cortex

  • Patrick May
  • Hannu Tiitinen
  • Risto J. Ilmoniemi
  • Göte Nyman
  • John G. Taylor
  • Risto Näätänen
Article

Abstract

We offer a model of how human cortex detects changes in the auditory environment. Auditory change detection has recently been the object of intense investigation via the mismatch negativity (MMN). MMN is a preattentive response to sudden changes in stimulation, measured noninvasively in the electroencephalogram (EEG) and the magnetoencephalogram (MEG). It is elicited in the oddball paradigm, where infrequent deviant tones intersperse a series of repetitive standard tones. However, little apart from the participation of tonotopically organized auditory cortex is known about the neural mechanisms underlying change detection and the MMN. In the present study, we investigate how poststimulus inhibition might account for MMN and compare the effects of adaptation with those of lateral inhibition in a model describing tonotopically organized cortex. To test the predictions of our model, we performed MEG and EEG measurements on human subjects and used both small- (<1/3 octave) and large- (>5 octaves) frequency differences between the standard and deviant tones. The experimental results bear out the prediction that MMN is due to both adaptation and lateral inhibition. Finally, we suggest that MMN might serve as a probe of what stimulus features are mapped by human auditory cortex.

adaptation auditory cortex change detection lateral inhibition mismatch negativity MMN 

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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Patrick May
    • 1
  • Hannu Tiitinen
    • 2
  • Risto J. Ilmoniemi
    • 3
  • Göte Nyman
    • 4
  • John G. Taylor
    • 5
  • Risto Näätänen
    • 6
  1. 1.Department of MathematicsKing's College London, StrandLondonUK
  2. 2.Cognitive Brain Research Unit, Department of PsychologyUniversity of HelsinkiFinland
  3. 3.BioMag Laboratory, Medical Engineering CentreHelsinki University Central HospitalHelsinkiFinland
  4. 4.Department of PsychologyUniversity of HelsinkiFinland
  5. 5.Department of MathematicsKing's College London, StrandLondonUK
  6. 6.Cognitive Brain Research Unit, Department of PsychologyUniversity of HelsinkiFinland

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