Skip to main content
SpringerLink
Log in

Discussion Article: A Global Collaboration on Carcinogenicity Screening in Transgenic Mouse Models

  • Published:
Transgenic Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Alden, C.L., Smith P.F., Piper, C.E. and Brej, L. (1996) A critical appraisal of the value of the mouse cancer bioassay in safety assessment. Toxicologic Pathology 24, 722-725.

    Google Scholar 

  • Ames B.N., and Gold, L.S. (1990) Chemical carcinogenesis: too many rodent carcinogens. Proc. Natl. Acad. Sci. 87, 7772-7776.

    Google Scholar 

  • de Vries, A., Van Oostrom, C.T.M., Dortant, P.M., Beems, R.B., Van Kreijl, C.F., Capel, P.J.A. and van Steeg, H. (1997) Spontaneous liver tumours and benzo(a)pyrene-induced lymphomas in xpa deficient mice. Mol. Carcinog. 19(1), 46-53.

    Google Scholar 

  • Donehower, L.A., Harvey, M., Slagle, B.L., McArthur, M.J., Montgomery, C.A., Butel, J.S. and Bradley, A. (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215-221.

    Google Scholar 

  • Feldmann, E.B. (1980) Carcinogenicity testing — a national disaster. J. Pharm. Sci., 69(2), i.

    Google Scholar 

  • Goodman, J.I., Ward, J.M., Popp, J.A., Klaunig, J.E. and Fox, T.R. (1991) Mouse liver carcinogenesis: mechanisms and relevance. Fundam. Appl. Toxicol. 17, 651-665.

    Google Scholar 

  • Leder, A., Kuo, A., Cardiff, R.D., Sinn, E. and Leder, P. (1990) v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid. Proc. Natl. Acad. Sci. 87, 9178-9182.

    Google Scholar 

  • Monro, A. (1993) How useful are chronic (life-span) toxicology studies in rodents in identifying pharmaceuticals that pose a carcinogenic risk to humans? Adverse Drug React. Toxicol. Rev., 12, 5-34.

    Google Scholar 

  • Saitoh, A., Kimura, M., Takahashi, R., Yokoyama, M., Nomura, T., Izawa, M., Sekiya, T., Nishimura, S. and Katsuki, M. (1990) Most tumors in transgenic mice with human c-Ha-ras gene contain somatically activated transgenes. Oncogene 5, 1195-1200.

    Google Scholar 

  • Sistare, F. (1998) Research on the identification of the non-responder phenotype. The TG.AC Workgroup Newsletter, 1(2), 2.

    Google Scholar 

  • Thomson, K.L., Rosenzweig, B. and Sistare, F.D. (1998) Qn evaluation of the hemizygous transgenic TG.AC mouse for carcinogenicity testing of pharmaceuticals II. Genotyping that predicts tumorigenic responsiveness. Toxicologic Pathology 26(4) (in press).

Download references

Author information

Authors and Affiliations

  1. CIT, Miserey, P.O. Box 563, 27005, Evreux, France

    Roy Forster

Authors
  1. Roy Forster
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Forster, R. Discussion Article: A Global Collaboration on Carcinogenicity Screening in Transgenic Mouse Models. Transgenic Res 7, 485–487 (1998). https://doi.org/10.1023/A:1008889427323

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1008889427323

Keywords

Search

Navigation