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Oral bioavailability of phenobarbital: a comparison of a solution in myvacet 9‐08, a suspension, and a tablet

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Abstract

Purpose: A three‐way crossover study with seven healthy male volunteers was conducted to determine the relative bioavailability of phenobarbital after single dose administration of 100 mg of phenobarbital as oral solution in Myvacet 9‐08, and as a suspension, compared with a 100 mg phenobarbital tablet. Materials and methods: At 4‐week intervals each subject received the solution in Myvacet 9‐08, the suspension and the tablet in randomized order. Blood samples were collected for 48 h after each dose for analysis of phenobarbital. From the individual serum concentration‐versus‐time curves C maxand T max were determined and AUC0‐48 was calculated. Results: All three oral dosage forms of phenobarbital are bioequivalent. No significant diffences in T maxwere observed. Conclusion: The oral solution in Myvacet 9‐08, and the suspension of phenobarbital proved to be bioequivalent to a tablet.

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Authors and Affiliations

  1. Department of Clinical Pharmacy, Rijnstate Hospital, PO Box 9555, 6800 TA, Arnhem, The Netherlands

    Jan Peter Yska, Guus W.G. Essink & Adriaan A. van Sorge

  2. Department of Internal Medicine, Rijnstate Hospital, 6800 TA, Arnhem, The Netherlands

    Frank H. Bosch

  3. Pharma Bio‐Research International B.V., 9470 AE, Zuidlaren, The Netherlands

    Gert Lankhaar

Authors
  1. Jan Peter Yska
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  2. Guus W.G. Essink
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  3. Adriaan A. van Sorge
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  4. Frank H. Bosch
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  5. Gert Lankhaar
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Yska, J.P., Essink, G.W., van Sorge, A.A. et al. Oral bioavailability of phenobarbital: a comparison of a solution in myvacet 9‐08, a suspension, and a tablet. Pharm World Sci 22, 67–71 (2000). https://doi.org/10.1023/A:1008770519585

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