Abstract
In the period July 1984 to June 1993 a total of 4541 admissions to a Department of Medicine for the Elderly were investigated. Approximately 9% of the total were diagnosed to have parkinsonism. Full drug histories together with the available demographic and clinical data were investigated in order to identify differences in the prescribing patterns in this group compared to those of non–parkinsonian patients admitted during this time frame. There was a statistically significant lower incidence among the parkinsonian group for the prescribing of all cardiovascular drug groups, anticoagulants, hypoglycaemics, bronchodilators, and corticosteroids compared with non–parkinsonian patients. In contrast, the incidence of hypnotics, laxatives, antidepressants and antipsychotics were significantly higher.
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References
Lawrence CJ, Trewin VF. Statistical methods in the construction of pharmacological reference ranges and their use in the identification of adverse drug reactions. Statist Applic 1990;2(4):333–49.
Trewin VF. The design of an algorithm for pharmacists to evaluate ADRs in the Elderly. J Clin Pharm & Therap 1991;16:45–53.
Duvoisin RC. Parkinson's Disease: A guide for patients and family. Raven Press: New York, 1978.
Montastruc JL, Chamontin B, Rascol A. Parkinson's disease and hypertension: Chronic bromocriptine treatment. Neurol. (Minneap.) 1985;35:1644–7.
Ziegler MG, Kennedy B, Holland OB et al. The effects of dopamine agonists on human cardiovascular and sympathetic nervous systems. Int J Clin Ther Toxicol 1985;23:175–9.
Iwasaki S, Hamaguchi K, Iwasaki A et al. Hypotensive effect of long-term levodopa in patients with Parkinson's disease. Europ Neurol 1990;30:194–9.
Durrieu G, Senard, JM, Tran MA et al. Effects of levodopa and bromocriptine on blood pressure and plasma catecholamines in Parkinsonians. Clin Neuropharmacol 1991;14:84–90.
Micieli G, Martignoni E, Bono G et al. A study of the cardiopressor effects of lisuride in the treatment of Parkinsonism and Pathological Ageing Brain. Clin Neuropharmacol 1989;12(5):404–15.
Abu-Jayyab AR. Insights on the mechanism of action of bromocriptine. J Pharm Med 1991;1:185–94.
Ramsay LE, Yeo WW, Jackson PR. Diabetes, impaired glucose tolerance and insulin resistance with diuretics. Europ Heart J 1992;13:68–71.
Sweet RD, McDowell FH. Five years' treatment of Parkinson's disease with levodopa. Ann Int Med 1975;83:456–63.
Berg MJ, Ebert B, Willis DK et al. Parkinsonism — Drug treatment: Part 1. Drug Intell Clin Pharm 1987;21:10–21.
Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology 1967;17(5):427–42.
Baldwin RC, Byrne EJ. Psychiatric aspects of Parkinson's disease. Br Med J 1989;299:3–4.
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Trewin, V., Lawrence, C., Abdulla, A. et al. Differences in drug prescribing patterns in elderly parkinsonian patients identified at hospital admission.. Pharm World Sci 19, 275–278 (1997). https://doi.org/10.1023/A:1008669826178
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DOI: https://doi.org/10.1023/A:1008669826178