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Calcium dobesilate-induced agranulocytosis.

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Abstract

Here we report a case of a patient in whom the administration of calcium dobesilate was associated with the development of an agranulocytosis episode. Eight weeks after the beginning of the treatment he was hospitalized with fever and leucopenia. Bone marrow biopsy showed a maturative promyelocytic interruption. All medication was withdrawn and blood cell count was completely recovered 7 days after admission. G‐CSF was administered. A detailed study was performed and causal relationship was not suggestive for the other three drugs the patient was receiving. To date, there have only been reported two cases of calcium dobesilate induced agranulocytosis.

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Authors and Affiliations

  1. Severo Ochoa Hospital, Avda. Orellana s/n. Leganés, 28911, Madrid, Spain

    Elena García Benayas, Benito García Díaz & Guillermo Pérez

Authors
  1. Elena García Benayas
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  2. Benito García Díaz
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  3. Guillermo Pérez
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Benayas, E.G., Díaz, B.G. & Pérez, G. Calcium dobesilate-induced agranulocytosis.. Pharm World Sci 19, 251–252 (1997). https://doi.org/10.1023/A:1008605208941

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  • DOI: https://doi.org/10.1023/A:1008605208941

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