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Bovine Herpesvirus Type 2 is Closely Related to the Primate Alphaherpesviruses

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Abstract

Bovine herpesvirus type 2 (BoHV-2), also known as bovine mammillitis virus, is classified in the Family Herpesviridae, Subfamily Alphaherpesvirinae, and Genus Simplexvirus along with herpes simplex viruses type 1 and 2 (HSV-1 and HSV-2) and other primate simplexviruses on the basis of similarities in 4 genes within the 15 kb UL 23–29 cluster. This could be explained either by a global similarity or a recombination event that brought primate herpesviral sequences into a bovine virus. Our sequences for DNA polymerase (UL30), a large gene adjacent to the previously identified conserved cluster, and glycoprotein G (US4), a gene as distant from the cluster as possible on the circularized genome, confirm the close relationship between BoHV-2 and the primate simplexviruses, and argue for a global similarity and probably a close evolutionary relationship. Thus one can speculate that BoHV-2 may represent a greater hazard to humans than has been appreciated previously.

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Authors and Affiliations

  1. Robert Koch-Institut, Nordufer 20, 13353, Berlin

    Bernhard Ehlers & Michael Goltz

  2. Department of Animal Health and Biomedical Sciences, University of Wisconsin-Madison, 1655 Linden Drive, Madison, WI, 53706

    Michael P. Ejercito, Gopal K. Dasika & Geoffrey J. Letchworth

Authors
  1. Bernhard Ehlers
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  2. Michael Goltz
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  3. Michael P. Ejercito
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  4. Gopal K. Dasika
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  5. Geoffrey J. Letchworth
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Ehlers, B., Goltz, M., Ejercito, M.P. et al. Bovine Herpesvirus Type 2 is Closely Related to the Primate Alphaherpesviruses. Virus Genes 19, 197–203 (1999). https://doi.org/10.1023/A:1008184630066

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